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Anyone on the Ascend Plus trial?

Mrs Redboots said:
I got so fed up of having to wake up at 06:30 to take my tablet that last night I did a bit of research on-line and discovered several peer-reviewed papers that say that levothyroxin works just as well if you take it at bedtime! So guess what I plan to do from tomorrow (I had to take eyedrops today - had a cataract removed last week - so didn't bother changing it for today)! So I can go back to waking at 07:00, taking the semaglutide then, and waiting the usual half an hour for my cup of tea!
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That's really good ! Can you let me know if you feel any difference taking it at night please it would be so much easier doing it that way x
 
klr said:
That's really good ! Can you let me know if you feel any difference taking it at night please it would be so much easier doing it that way x
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They do say that it ought to be taken at least 2 hours after eating, so if you're in the habit of a bedtime snack (I very seldom have one), it might not work. I'm on such a tiny dose, though, that I can't see it makes much difference - and one friend, who didn't know about the 30-minute restriction, was in the habit of taking hers with her morning coffee, and her doctors don't seem to have noticed...
 
Morning, I am having the usual side effects and trying to manage them but wondered if anyone else is struggling with sleep issues. I am going to bed between 10.30and 11pm usually and can get to sleep. However, I am waking up between 3 and 4 am most nights and really struggle to go back to sleep. I don’t eat after 7pm and wonder if it is anything to do with low blood sugars overnight now I am on the trial drug. I also take metformin and jardience. I don’t have a tester for checking as diabetic nurse felt it was not needed.
 
Good afternoon. I wonder if you could answer a few questions? I have been chosen to take place in the trial and waiting for a response. If I am suitable, and I decide to go ahead, how does the scheme work? Are you sent the medication through the post or is it a prescription? TIA
 
You are sent it through the post.
 
Jibba Jabba said:
Good afternoon. I wonder if you could answer a few questions? I have been chosen to take place in the trial and waiting for a response. If I am suitable, and I decide to go ahead, how does the scheme work? Are you sent the medication through the post or is it a prescription? TIA
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Medication is sent through the post
 
Sally66 said:
Just thought aid start a discussion here for anyone on the Ascend Plus trial by Oxford University.

Started my “Run In” phase yesterday and so far so good. No side affects other than fatigue. How are other folks doing?
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Hi i am into my 4th month on the trail i suffered from shakes to start with and now i get the hiccups. I gave reduced my diabetes tablets and to top it off i gave lost 19lb. Keep at it
 
PaulineHarrington said:
Morning, I am having the usual side effects and trying to manage them but wondered if anyone else is struggling with sleep issues. I am going to bed between 10.30and 11pm usually and can get to sleep. However, I am waking up between 3 and 4 am most nights and really struggle to go back to sleep. I don’t eat after 7pm and wonder if it is anything to do with low blood sugars overnight now I am on the trial drug. I also take metformin and jardience. I don’t have a tester for checking as diabetic nurse felt it was not needed.
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Hi yes I am on the second month of 14mg or placebo and I am going to bed similar time as you . On most nights I now wake at 3am virtually on the dot ,don't know why I never did before. It isn't every night but most. However I can go back to sleep but it takes a while.
 
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