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  1. MarkMunday

    Does active preservation of the honeymoon period improve lifetime prognosis?

    There is not much data around on this, mainly because people who have lived with T1 for 50+ years have had to use relatively poor methods of control for much of their T1 duration. So making comparisons is difficult. Perhaps the best source of info on this is the ongoing Joslin Diabetes Medalist...
  2. MarkMunday

    Strategy for getting R insulin (UK NHS)

    This is the conventional wisdom, which is not based on fact. Brain cell death is thought to occur when blood glucose drops below 1 mmol/l. Most hypos are treated well above this level. People with hypoglycemia awareness can function normally at 2 mmol/l with full cognitive function and no brain...
  3. MarkMunday

    Does active preservation of the honeymoon period improve lifetime prognosis?

    How long it takes for insulin production to shut down completely depends mostly on two things. Age at diagnosis and the level of blood glucose control. Diagnosis in adulthood usually means a longer honeymoon, and it can continue for many years. On the other hand, blood glucose toxicity kills...
  4. MarkMunday

    Hypo

    Reread my posts. I never said ignore hypos. I said don't be afraid of them and I explained why. The misinformed alarmist narrative doesn't do any favours. Especially to parents and young people with T1. It causes anxiety, depression and corresponding mental health issues. Instilling unwarranted...
  5. MarkMunday

    Hypo

    Not sure what you are getting at. Yes, the pancreas is not able to quickly detect insulin injected under the skin. The result of this is that glycogenolysis (conversion of liver glycogen to glucose) is not inhibited after injecting insulin. Blood glucose goes too high because of excess liver...
  6. MarkMunday

    Hypo

    No one disagrees with that. However, it is helpful to understand what happens during hypos so we know what risk may be involved should a hypo not be promptly treated. The unpleasant and scary hypo symptoms we all have experienced are not actually caused by the brain being starved of glucose...
  7. MarkMunday

    Hypo

    Hypos come with the territory, they can have unfortunate consequences and must be avoided if possible. The important point is that if, for whatever reason, a hypo is not treated you will survive. The average liver can supply 130 grams of glucose, enough to deal with a severe hypo. In the absence...
  8. MarkMunday

    Strategy for getting R insulin (UK NHS)

    Regular (Actrapid, Novolin R or Humalin R) has always been more suitable when fat is the main source of energy. Doctors don't like it because the longer action profile causes hypos when used with high carb meals. You just have to explain that you don't eat high carb meals. If you explain your...
  9. MarkMunday

    Right, when do you stop the fixed doses

    It is up to you really. Whatever puts you in control and provides you with the freedom you want. Don't expect to get detailed directions on this. We are all different and have to figure out what works best. Test and measure.
  10. MarkMunday

    Strategy for getting R insulin (UK NHS)

    Explain your reasons to your doctor. I use Lantus, regular and Novorapid. I need all three to get the control I want. After explaining the requirement, the endocrinologist and prescribing nurse here in New Zealand were happy to give me what I need. Regular (Actrapid) is cheaper than the faster...
  11. MarkMunday

    Hypo

    Why not? It happens to all of us every night. After carbohydrate from the last meal has been used up, blood glucose falls and blood glucose falls. The liver releases glucose to keep the body ticking over while we sleep and until breakfast. You ever heard a non-diabetic not waking up because of...
  12. MarkMunday

    Hypo

    Sounds like you could be getting too much basal insulin action overnight. Basal testing would help figure that out. It helps to ensure basal coverage is good before changing carb ratios and boluses. You may not even need to change it.
  13. MarkMunday

    Some guidance please

    There could be some reactive hypoglycemia there too. With such small insulin dosages, you must still have a lot of beta cells. When you eat lots of carbs, these beta cells make lots of insulin, which sometimes makes you go hypo. During the so-called honeymoon, this effect is often inconsistent...
  14. MarkMunday

    Bedtime bloods

    It will only work if your blood glucose is high before bed because the liver is making too much of it. Could the cause be what you ate for dinner? Cutting carbohydrate for dinner maybe more effective. (edited by mod.)
  15. MarkMunday

    Hypo

    Why is it worrying? It looks like your liver supplied the required glucose and you came out of the hypo. This is what is supposed to happen.
  16. MarkMunday

    T1D-Weight gain— insulin aspart + glargine

    Eating so much carb is putting the weight on. Stop it by reducing carb and insulin at the same time. Insulin is an anabolic hormone and promotes muscle growth, but only if suitable resistance exercise is done. Bodybuilders often supplement with it and increase carbs too.
  17. MarkMunday

    Hypoglycemia reverse hyperglycemia

    You really need to figure this out for yourself and do what works best for your child. Fasting only works if basal insulin supply and requirement are closely matched. Achieving this in in children is difficult because of activity levels and hormonal activity. As growth hormone drops, sex...
  18. MarkMunday

    Doing a fasting test today

    Presumably the logic is that low fasting blood glucose and high insulin levels may mean insulinoma. That your fasting blood glucose is normal suggests this is not the case. Your previous experience with blood glucose dropping suggests the opposite. It may help to use a Libre CGM for a while so...
  19. MarkMunday

    Should I still take insulin if fasting?

    We learn something from making changes if we change only one thing at a time. Having diabetes means being on a never eding learning curve, which we move up by changing one thing at a time. I would continue with insulin and medication while starting keto/if, do regulat testing, and see what...
  20. MarkMunday

    C peptide and GAD antibodies back

    Yes, your basal dose will probably double and you will start mealtime bolus insulin too. Bolusing before meals will make achieving control a lot easier. You will start adjusting dosage and timing of shots based on test results, which gives us control over blood glucose. Figuring it out is a...
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