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A radically different response to the same dose of insulin.

DraguAlex

Newbie
Messages
3
Type of diabetes
Type 1
Treatment type
Insulin
Hello, have you encountered this issue before? My insulin doses are changing significantly. Just a week ago, I was taking 14 units in the morning, and now I'm taking 8. Last night, I took 12 units of Fiasp for 70 grams of carbohydrates, and my blood sugar went from 250 to 400. Today, from 250, it dropped drastically, almost causing hypoglycemia, with an 11-unit insulin dose. Sometimes the insulin takes effect after 4-5 hours, and I have a very high peak, while other times it drops immediately within an hour and tends toward hypoglycemia if I don't eat something. I have had diabetes since I was 8 years old, and now I'm 23. I have never experienced anything like this before. Could it be Mody? Or is it possible that Tresiba basal insulin is no longer compatible with me?
 
Hi @DraguAlex , welcome to the forum.

I think MODY would be very unlikely, considering you've been T1 since you were 8 years old.

If you've never experienced those kind of changes before, something odd seems to be going on. Have you done any basal testing lately to see if your dose of Tresiba is still keeping you level without food?
Are you making sure to rotate injection sites?
 
Hi @DraguAlex , welcome to the forum.

I think MODY would be very unlikely, considering you've been T1 since you were 8 years old.

If you've never experienced those kind of changes before, something odd seems to be going on. Have you done any basal testing lately to see if your dose of Tresiba is still keeping you level without food?
Are you making sure to rotate injection sites?
I always change the injection site, sometimes my blood sugar level increases between meals, and sometimes it decreases. I don't understand anymore. Can Tresiba overlap?
 
Ouch, are you able to contact your diabetic team (hospital, not GP)?

Insulin doses can vary dramatically (temperature, exercise,illness etc).

Some people need to change their insulin type.. Tresiba also isn't ideal if your insulin needs vary, (wouldn't work for me) so I urge you to contact your diabetic team to discuss your issues.
 
Ouch, are you able to contact your diabetic team (hospital, not GP)?

Insulin doses can vary dramatically (temperature, exercise,illness etc).

Some people need to change their insulin type.. Tresiba also isn't ideal if your insulin needs vary, (wouldn't work for me) so I urge you to contact your diabetic team to discuss your issues.
I was admitted in Bucharest, Romania, but when I got home, my doses were drastically reduced. Other doctors say that I might have developed another type of diabetes (MODY). I'm going to talk to a professor doctor, and if I still don't succeed, I will go to Italy for treatment.
 
Are you eating exactly the same food after sleeping exactly the same number if hours in exactly the same heat with exactly the same amount of stress following a day doing exactly the same amount of exercise whilst exactly the same level if healthiness?
There are many things (more than I have listed) which can affect our blood sugars and insulin sensitivity.
If I am ill I can use twice as much insulin. If I exercise, I experience no dawn phenomenon. If I sleep badly, I can experience a huge fotf spike
 
Hello @DraguAlex

Tresiba has very little/no impact on the action of the quick acting insulin. However the action of quick acting insulin can be (as explained above) be affected by many things, stress/hormones/heat/exercise as well as what you eat, so if you eating a meal with fat in that can delay the action of the glucose release from carbohydrates causing an initial drop and a high later.

When you are first diagnosed you will experience a honeymoon phase too where taking insulin means a less stress pancreas which will kick into gear again with insulin production so insulin needs drop alot, it will eventually end but it does cause different reactions to quick acting insulin which may well be what is happening right now.

I used to take tresiba and found it to be the best basal insulin due to it's stability over 36+ hours, but you need to do basal fasting tests to check it from time to time to ensure you're taking the right dose.
 
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