Anyone on the Ascend Plus trial?

[Doddsy1967]

So I started taking the meds on the 7th Nov, my appetite has been considerably reduced, but this only really kicked in last week, guess it takes a while to work. I am going for my Diabetic MOT on the 12th December and I'll keep you posted on the results ..only thing I can say is that I have a bitter taste most of the time at the back of my throat, but so far no other issues. I'm excited where this journey is taking me !!

Hi I started the run in phase about early October on the first 3 mg phase I noticed nothing then the second 7 mg phase I noticed a lack of appetite particularly in the evening I could easily have passed on dinner. I don’t need or want to lose weight but have last half a stone on phase 2. The only side effect other than appetite on this phase has been some hypos.
I received the randomisation 14mg and appetite has returned and hypos have gone. The randomisation questionnaire was the first time I have been asked my bmi. All the pills have been very bitter pills to swallow. I feel I’m on the placebo now but I’ll see the trial through. It’s a good thing to do I think.

 

[Tepidsprat]

Good afternoon all,
Started the trial in late Nov 25 and have just started the 2nd bottle of the trial package. Since taking the 2nd bottle, i feel slightly nauseous constantly and really don't have any appetite whatsoever. Will this feeling go away at all? I weighed myself over Christmas and was down to 11st 11lb, which is the lowest i have been since my early 20's.

 

[Doddsy1967]

Hi yes I started the 3 mg bottle in October I didn’t notice anything then onto the 7 mg and felt a bit nauseous at first and a drop off with appetite mostly in the evenings I lost half a stone down to 12st 1 (I’m 6’2) my weight stays constant usually I am now on the 14 mg trial pack of active drug or placebo.. it still tastes bitter as hell but I’ve noticed my appetite has returned so unsure if it’s placebo or semiglutide but I’ll continue with it until the end

 

[RAD123]

Good afternoon all,
Started the trial in late Nov 25 and have just started the 2nd bottle of the trial package. Since taking the 2nd bottle, i feel slightly nauseous constantly and really don't have any appetite whatsoever. Will this feeling go away at all? I weighed myself over Christmas and was down to 11st 11lb, which is the lowest i have been since my early 20's.

The sickly feeling for me has never gone but you get used to it in the background. It does accelerate if you eat the wrong food though . Also some fizzy drinks. Good luck.

 

[Doddsy1967]

Thanks and you. I think it’s a worthwhile thing to do unless the side effects are unbearable

 

[tonyglover6861]

Just thought aid start a discussion here for anyone on the Ascend Plus trial by Oxford University.

Started my “Run In” phase yesterday and so far so good. No side affects other than fatigue. How are other folks doing?

I'm on it as well and just moved from the 3mg run in to the 7mg dosage. I don't read side effects as it's usually a trigger for me to experience them all! However I have been 'fatigued' and had a 'heavy' tiredness as well as fidgety sleep, plus a loss of appetite but feeling full a lot quicker when I do eat. My blood sugars have been fine but prior to this trial I had gone from HBA1C of 50 to 37 in a year through diet and exercise . I decided to check the potential side affects anyway, and yes everything I'm experiencing is 'normal' as it's more likely when you move from the initial 3mg run in dosage to the 7mg. It's part of the bodies adjustment phase and lasts 1-2 weeks...I'm just over a week into 7mg. Checking my weight shows I'm the same as just befre Christmas so I'm happy it's all working as I go back to my normal regime from yesterday.

 

[Mrs Redboots]

I'm now in the first week of the randomisation tablets, which I started on Sunday. I thought at first they must be the placebo, as they didn't taste bitter - but later that afternoon I started to feel slightly sick, and since then I have had those odd not-quite-burps-not-quite-hiccups and occasional spasms of mild nausea (having one at the moment, which is what reminded me to come on here. Plus some constipation, and equally some diarrhoea! I also still have little appetite, although I have felt hungry a time or two this week. So I think I might well be on the 14 mg - I do hope so.

I definitely lost weight while on the running-in phase - I can look at myself sideways in the mirror without wincing! I really ought to buy a pair of bathroom scales, but so depressing when one is still AT LEAST 15 kg overweight! It's great to have lost.... but a long way still to go.

I never thought I'd be glad to feel sick!!