I did 3 months in the Ascend Plus trial and was randomised onto the placebo and my appetite came back and I gained most of the weight I had lost.  Although when I was on it, my HbA1c was the best it had been in years.  Persuaded my GP to prescribe it for me even though I didn't quite meet the criteria but have terrible stomach problems on metformin. 
I had two months on the 3mg (as I was away for 3 weeks and didn't want to increase the dose whilst I was away) and am half way through first month on 7mg.  I have no appetite and have to be careful not to eat too much otherwise my stomach complains.  I get the occasional burpy feeling and sometimes a bit of an acid stomach, but I'm prepared to stick with it as I have lost 8kg.  I get my HbA1c checked in April, so hoping for a similar one to when I was on the trial.