Bgs below traditional diabetes cut offs can cause damage

Tannith said:

I was prompted by a post in the thread "cured" to look again at the traditional FBG cut off points for T2. Some may find this article interesting:
Glucose can also start killing beta cells at levels below 140. One study found that people with fasting blood glucose from 110–125 (within the official “prediabetic” range) had already lost up to 40% of their beta cell mass.

Italian researchers found that even with glucose levels in the supposedly “normal” range, beta cells started to fail. Ruhl says that researchers “found that with every small increase in the 2-hour glucose tolerance test result, there was a corresponding increase in…beta cell failure. The higher a person’s blood sugar rose within ‘normal’ range, the more beta cells were failing.”

Failing beta cells will lead to worsening diabetes, a truly vicious cycle. Slightly elevated glucose has also been shown to cause eye damage (“retinopathy”) and increased rates of heart disease, kidney damage, and stroke.

https://www.diabetesselfmanagement.com/blog/new-research-on-high-glucose-levels/

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Tannith said:

I was prompted by a post in the thread "cured" to look again at the traditional FBG cut off points for T2. Some may find this article interesting:
Glucose can also start killing beta cells at levels below 140. One study found that people with fasting blood glucose from 110–125 (within the official “prediabetic” range) had already lost up to 40% of their beta cell mass.

Italian researchers found that even with glucose levels in the supposedly “normal” range, beta cells started to fail. Ruhl says that researchers “found that with every small increase in the 2-hour glucose tolerance test result, there was a corresponding increase in…beta cell failure. The higher a person’s blood sugar rose within ‘normal’ range, the more beta cells were failing.”

Failing beta cells will lead to worsening diabetes, a truly vicious cycle. Slightly elevated glucose has also been shown to cause eye damage (“retinopathy”) and increased rates of heart disease, kidney damage, and stroke.

https://www.diabetesselfmanagement.com/blog/new-research-on-high-glucose-levels/

Click to expand...

Mr_Pot said:

I thought the problem with research into beta cells dying was that there was no way to measure it apart from an autopsy. What technique did they use?

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Antje77 said:

From the first link in Tannith's post:

"At the Mayo Clinic some of these difficulties are overcome. Autopsies are performed within 12 h of death (usually <6 h), including weekends. The Mayo Clinic integrated medical record system allows easy access to the prior clinical records of the cases. As the Mayo Clinic tends to be the primary health care provider for people hospitalized at the medical center for their final illness, most of the autopsy cases have had a general medical examination (including a fasting blood glucose) during the year before death.

In the present study, we took advantage of the unique autopsy material available at the Mayo Clinic to study 124 human pancreata from cases with and without diabetes and matched for obesity. All cases had a well-preserved pancreatic specimen and documented general medical exam, including a fasting blood glucose obtained during the 12 months before death."

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β-cell mass in human pancreas can be measured by volumetric morphometry and roughly consists of 250 thousand to one million pancreatic islets or around 250 million to one billion β cells 9,10. In a study of 52 non-diabetic adult humans β-cell mass varied considerably ranging from 0.25 to 1.5 gm

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With the insulin resistance of obesity, a given β-cell mass chronically secretes more insulin. β-cell mass as determined from study of cadaver pancreases is increased in obese subjects, but only modestly, with estimates being only about 20–50% more than that of normal weight individuals 11,12,31. Yet, the rate of insulin secretion over a 24-hour period is 100% more than normal

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There have been a number of hemi-pancreas transplants done in humans such that individual donate about 50% of their pancreas to a recipient with T1D, but it has become clear that the donors have increased risk of developing diabetes. A follow-up study published in 2008 evaluated 15 donors who had hemi-pancreatectomies at the University of Minnesota between 1997 and 2003, with the finding that 43% had either glucose intolerance or diabetes 82. Another study followed 37 patients after removal of about 50% of their pancreases for either benign or malignant neoplasms and found similar results

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lucylocket61 said:

Would anyone care to translate the numbers into UK ones please?

70 appears to be 3.9 which even my non diabetic people don't get as a rule, so how can it be a dangerous level?

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Tannith said:

My FBG was 5.6 this morning on waking.

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