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Could THIS be a cure for diabetes? New drug 'cocktail' may boost insulin production by 40-fold

Yet "another miracle cure"

Interesting in there is the line:

"Dr Stewart says one challenge, however, is that this drug combination has effects on other organs, although he didn't specify what those effects were."

No I don't think it is "cure" the article seems a mish mash of information but even if they do stop effect on other organs you be lucky to see this in 20+ years.
 
My takeaway is that while new beta cells would be wonderful for T1s, the trick would be to stop the immune system killing them all off as quickly as they grow.

While for T2s, it all depends on how much more insulin resistance you want to create. More beta cells and more insulin means more insulin resistance, and an escalation of complications.

So I am definitely not seeing anything like 'a cure'.
 
Simply put,

It all looks a little blinkered to me..? What about insulin resistance in T2 & the threat & autoimmune response in T1???

From the second link.
"In a major new study, Stewart argues that that’s enough to normalize blood sugar in diabetics. The drugs have made human beta cells replicate in petri dishes, transplanted mice and several other ways."
 
Apologies for going off topic.
But apparently Elvis is alive and living on the moon.
Like the aforementioned article, until I actually have unequivocal proof I will remain slightly doubtful.
 
After two years of eating low carb my insulin levels seem to have dropped low enough for my receptors to allow it to work again - more insulin is the last thing I need as a type two.
I can only go by my reaction to food, and small amounts of carbs seem to be dealt with as normal - slammed straight into my fat reserves (I should try not to feel aggrieved about it) but I really think that my present situation is the better option, not more insulin.
 
A lot of diabetes type conditions including T2, is caused by hyperinsulinaemia.
You get to that stage because of insulin resistance, too much insulin.
The reason hyperglycaemia happens is because of insulin resistance.
This imbalance impairs first insulin response and glucose levels spike too high.
However, drugs have been created, such as gliptins, to improve initial insulin response.
This will reduce the spike derived from the meal. The amount of insulin created after initial response is lower than before. Which in return if a lower carb diet is adopted will help with glucose and insulin levels.

This is happening now, so is research into other drugs, also because diabetes is so individual, tailored drugs will become a future treatment.

I'm not going to comment on this report.
 
My first reaction was to be highly sceptical but on reflection as an myasthenic I take mestinon (Pyridostigmine) to slow down or block the breakdown of Acetylcholine so as to increase the amount available to me and I take immunosuppressants to prevent the immune system from attacking the Acetylcholine receptors and to an extent it works quite well and essentially this would not be much different in a round about way.

But in T1 diabetes you would I think have to suppress the immune system.
 
therower said:
Apologies for going off topic.
But apparently Elvis is alive and living on the moon.
Click to expand...
Elvis is not living on the moon, there is no air on the moon. He is living on every second street corner in Las Vegas and in every wedding chappel there, I have seen him with my own 2 eyes and no my eyes have not as yet been effected by diabetes. Poor Elvis is working so hard he is at serious risk of a big heart attack.
 
I am concerned that it is using the same mechanisms for cell growth as cancer, What is to prevent the newT-Cells from taking over the planet?
 
Chowie said:
Elvis is not living on the moon, there is no air on the moon. He is living on every second street corner in Las Vegas and in every wedding chappel there, I have seen him with my own 2 eyes and no my eyes have not as yet been effected by diabetes. Poor Elvis is working so hard he is at serious risk of a big heart attack.
Click to expand...
No air on the moon?????? So how do the Clangers survive then smarty pants?:)
If, and it’s a big IF Elvis is moonlighting in Vegas being as busy as you state then it sounds like he hasn’t even got time to go toilet. ( Which may be a good thing;))
 
Chowie said:
Elvis is not living on the moon, there is no air on the moon. He is living on every second street corner in Las Vegas and in every wedding chappel there, I have seen him with my own 2 eyes and no my eyes have not as yet been effected by diabetes. Poor Elvis is working so hard he is at serious risk of a big heart
Click to expand...

Your own 2 eyes?
upload_2018-12-22_20-17-52.png
 
Andrew Stewart, MD, Director of the Mount Sinai Diabetes, Obesity, and Metabolism Institute and lead author of the study who lead - with his team - this experimental researches says : " “Since these drugs have effects on other organs in the body, we now need to develop methods to deliver these drugs specifically to the beta cell in humans,” said Dr. Stewart. “We have the packages to deliver, but now we need a courier system to deliver them to the exact beta cell address.” quotation from Mount Sinai article link : https://www.mountsinai.org/about/ne...-human-beta-cell-proliferation-at-rapid-rates

this mission I think could be achieved by using mico robots like this one :
 
I believe we could get pretty decent glucose control with 30% functional beta cells and some dietrary control...so for T1D, with beta cells growing at 5% per day...that sounds really promising. The next step is to deal with the autoimmune issue..

But for T2D, it is really to deal with chronic excessive insulin. Pumping out more insulin may lead to the same results as the ACCORD study...not to mention cancer risks from possible over proliferation of beta cells...
 
Khaled1972 said:
. . . . . new drug could cure T1 and T2 diabetes :
Click to expand...

Cure: Relieve (a person or animal) of the symptoms of a disease or condition.
‘he was cured of the disease’
Eliminate (a disease or condition) with medical treatment.
‘this technology could be used to cure diabetes’

They seem to have lumped the two diseases together and so long as the problem is the lack of beta cells producing insulin, then this might be an advance in the right direction. However, producing more insulin for a type II might not be the best idea, whereas it is my opinion that reducing the need for insulin is.

From the second link: What they have in common is that eventually the diabetic runs out of insulin-producing cells called beta cells.

I recently went to a presentation given by an endocrinologist who said that all type IIs will end up on insulin in 10 to 15 years. I'm pleased to say that it's now been 21 years since diagnosis and my only regret is that I didn't "disobey" my GP's advice not to cut carbs a lot earlier. It would have saved me from considerable weight problems.

 
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