No, not at all.
The problem with Dr. Fung's argument is that there are two pathways to how the cell responds to insulin. The FoxO1 pathway for glucose and the mTORC1 pathway for lipids. The FoxO1 becomes resistant causing the glucose rise, but the non-resistance mTORC1 responds to the additional insulin causing additional lipogenesis. So there is no inherent contradiction as Dr. Fung claims: the cell is responding to insulin via the 'fat-producing' pathway while ignoring the glucose pathway.
That doesn't mean that his methods don't work and clearly do work for a lot of people, but his scientific explanation is not correct. Selective hepatic resistance which he calls a 'house build on no foundation' is precisely what you'd expect from the FoxO1/mTORC1 pathway 'split'. There is clearly
a lot more going on at the cellular level. Read that paper then decide whether these scientists haven't considered such issues.
However, clearly the insulin resistance is a key component and the resulting insulin overproduction and understanding why the FoxO1 pathway stops responding is key, and he is certainly correct that we need to find ways to improve/normalize insulin sensitivity. Clearly, losing weight is a key element which is probably why both his and Dr. Taylor's work have shown success.
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