Oldvatr
Expert
- Messages
- 8,453
- Type of diabetes
- Type 2
- Treatment type
- Tablets (oral)
I am not sure this is addressing the condition known as IR. Certainly building up muscles will increase the potential for better glucogen storage, but I see nothing that shows that T2D IR will necessarily be improved by exercise, There is a link to a referenced study in the margin of the abtract, but the link does not appear to be functioning, so I cannot access that report,Hello Again @Oldvatr,
I'm still looking into my original question trying to find a reference to cell utilization of glucose with and without the presence of insulin. I agree with you that glucose uptake and utilization are two different things. Haven't found anything about insulin actually being physically present inside the cell to instruct enzymes to catalyze glucose or attach to an existing glycogen molecule. If I'm understanding you correctly (given that the body burns only ATP not glucose) the presence of insulin prohibits the conversion of glucose into ATP?
Sorry it's hard to process everything your saying at one time so I'll need to digest it a little bit at a time.
Great image of glycogen molecule inside muscle cell; can store about 30,000 glucose molecules in an amazing little sphere. Building muscle size through exercise increases the number of these in each muscle cell. Thanks to Häggström, Mikael (2014). "Medical gallery of Mikael Häggström 2014".
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YET Another Edit: Woo-Woo!! Just found this and looks like a positive endorsement to reduce IR with exercise from: https://www.ncbi.nlm.nih.gov/pubmed/23899560 .. A portion of it is:
"Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease." Whoops - they meant to say "conditions" not "disease":![]()
Finally a study that discusses T2 IR effects and GLUT4
http://www.sciencedirect.com/science/article/pii/S1550413107000678
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