High Uric Acid Causes Insulin Resistance

[TwoTone]

I’ve been searching for a while for what causes insulin resistance but not had much luck. Just this last weekend I found some research.

Background. Five years before being DX’D as T2D in Nov 2004, I was DX’d with gout. Gout is caused by high levels of serum uric acid. Uric acid is produced by the liver by processing ingested purines and then cleared out of the body - through peeing. If uric acid in the blood gets too high it crystallizes in the joint - more often the big toe but others too.

Uric acid can also be high without causing gout. I had been in this position a few years ago. I now take 100mg of allopurinol each morning. There is a strong connection between diabetes and gout:

https://www.diabetes.co.uk/conditions/gout-and-diabetes.html

I did a search of “uric acid insulin resistance” and got many hits of research material stating URIC ACID CAUSES INSULIN RESISTANCE! Examples…

https://www.frontiersin.org/articles/10.3389/fendo.2018.00098/full

https://www.nature.com/articles/s41598-018-29955-w

Highest levels of purines are found in meat products and some veggies. Purines come from foods we eat…

https://elevatehealthaz.com/wp-content/Purine Table.pdf

Another source of purines is fructose (bad stuff in large quantities)

My own testing has shown that when I stopped eating meat two years ago, my blood glucose levels and HbA1c, went down. When I ate Xmas cake (raisins, current, nuts and sugar free), my HbA1c went up. It’s now gone back down again.

It may be worthwhile concentrating harder on treating the uric acid levels - I have a uric acid level test with he HbA1c test every 3 months. I need to have a conversation with my GP about this.

Interestingly, a treatment for gout, colchicine, is being tested (clinical trials) as a treatment for COVID-19 here in Canada.

Stay safe everybody.

 

[Tophat1900]

Low carb/keto has shown over and over to be very effective at reversing/remission of T2 or at least reducing medications.... if purines were a problem then we wouldn't be seeing the success we are with LC, KETO and now carnivore diets on all aspects of health markers.

Insulin resistance comes from excessive production of insulin by the pancreas from eating excessive amounts of carbs (whether it be grains, sugary drinks, chocolates etc). So, weetbix, bread, rice, potatoes, pasta are all high carb examples. As are your popular drinks like coke, fruit juices etc. The more carbs you eat, the more insulin is required, the more frequently you eat these choices the less of a break the pancreas gets. This is the road to insulin resistance.

I think what should be concentrated on is diet. LC/Keto approach. This has a proven track record of success, so what works is what should be concentrated on imo if the person wants that option.

I've had high uric acid levels for a long time with 37 being a constant number. Ref range is 0.15 - 0.50 on my test results. High is considered 0.38 and above. However, once I started supplementing with K2-mk7 in particular that number dropped to 0.27 and has remained so for the last 6 months or more. My diet remains keto. There have been no changes at all, except adding the k2. So, I credit the lowering of the uric acid level to the K2, obviously I cannot prove it, but it is imo just one of the many benefits of k2. And with the added bonus of not being a drug.

 

[Grant_Vicat]

I’ve been searching for a while for what causes insulin resistance but not had much luck. Just this last weekend I found some research.

Background. Five years before being DX’D as T2D in Nov 2004, I was DX’d with gout. Gout is caused by high levels of serum uric acid. Uric acid is produced by the liver by processing ingested purines and then cleared out of the body - through peeing. If uric acid in the blood gets too high it crystallizes in the joint - more often the big toe but others too.

Uric acid can also be high without causing gout. I had been in this position a few years ago. I now take 100mg of allopurinol each morning. There is a strong connection between diabetes and gout:

https://www.diabetes.co.uk/conditions/gout-and-diabetes.html

I did a search of “uric acid insulin resistance” and got many hits of research material stating URIC ACID CAUSES INSULIN RESISTANCE! Examples…

https://www.frontiersin.org/articles/10.3389/fendo.2018.00098/full

https://www.nature.com/articles/s41598-018-29955-w

Highest levels of purines are found in meat products and some veggies. Purines come from foods we eat…

https://elevatehealthaz.com/wp-content/Purine Table.pdf

Another source of purines is fructose (bad stuff in large quantities)

My own testing has shown that when I stopped eating meat two years ago, my blood glucose levels and HbA1c, went down. When I ate Xmas cake (raisins, current, nuts and sugar free), my HbA1c went up. It’s now gone back down again.

It may be worthwhile concentrating harder on treating the uric acid levels - I have a uric acid level test with he HbA1c test every 3 months. I need to have a conversation with my GP about this.

Interestingly, a treatment for gout, colchicine, is being tested (clinical trials) as a treatment for COVID-19 here in Canada.

Stay safe everybody.

Interesting thought @TwoTone . My only experiences of gout all occurred in the 4 years leading up to my kidney transplant after 54 years of Type 1. In the final months I had frequent attacks which could appear in the toes or arches of either foot, in either hand, in the chin, or worst of all in the sternum, rendering breathing, sneezing or laughing an ordeal. On one occasion I had it in the foot, elbow and left hand simultaneously. Since the transplant, I have had no problems at all. Admittedly I am no longer affected by diabetes Type 1, thanks to a pancreas transplant and have not had a uric acid test for over 6 years. Throughout my life sardines and tuna in oil have been a staple until a low protein/phosphate diet ruled them out. Likewise red meat and fruit. They have all returned! I stuck to a carbohydrate controlled diet from 1966 onwards and in many ways still take in 245g spread at even timings each day. I would not say my experience would contra-indicate any research findings, but as in so many cases demonstrates variations in metabolism etc. Good luck with your health!

 

[TwoTone]

Low carb/keto has shown over and over to be very effective at reversing/remission of T2 or at least reducing medications.... if purines were a problem then we wouldn't be seeing the success we are with LC, KETO and now carnivore diets on all aspects of health markers.

Insulin resistance comes from excessive production of insulin by the pancreas from eating excessive amounts of carbs (whether it be grains, sugary drinks, chocolates etc). So, weetbix, bread, rice, potatoes, pasta are all high carb examples. As are your popular drinks like coke, fruit juices etc. The more carbs you eat, the more insulin is required, the more frequently you eat these choices the less of a break the pancreas gets. This is the road to insulin resistance.

I think what should be concentrated on is diet. LC/Keto approach. This has a proven track record of success, so what works is what should be concentrated on imo if the person wants that option.

I've had high uric acid levels for a long time with 37 being a constant number. Ref range is 0.15 - 0.50 on my test results. High is considered 0.38 and above. However, once I started supplementing with K2-mk7 in particular that number dropped to 0.27 and has remained so for the last 6 months or more. My diet remains keto. There have been no changes at all, except adding the k2. So, I credit the lowering of the uric acid level to the K2, obviously I cannot prove it, but it is imo just one of the many benefits of k2. And with the added bonus of not being a drug.

Hi Tophat1900. I'm wondering if you could point me to material describing the high insulin levels causing insulin resistance. I'm interested in reading about this. I'm also interested in learning about the effects of K2-mk7. I currently take allopurinol to manage uric acid.

And yes, I've been on a carb controlled diet for a low time but experienced ever increasing meds (metformin) over the last 15 years. Just looking to keep things under control.
Stay safe.

 

[Brunneria]

Hi Tophat1900. I'm wondering if you could point me to material describing the high insulin levels causing insulin resistance. I'm interested in reading about this. I'm also interested in learning about the effects of K2-mk7. I currently take allopurinol to manage uric acid.

And yes, I've been on a carb controlled diet for a low time but experienced ever increasing meds (metformin) over the last 15 years. Just looking to keep things under control.
Stay safe.

jason Fung (nephrologist and intermittent fasting expert) has a superb blog with huge amounts of information on this. He also lectures, has published several books now and runs a clinic.

He discusses the intricacies of insulin resistance in a series of blog posts with good referencing.
https://thefastingmethod.com/?s=Insulin+resistance

 

[Tophat1900]

Hi Tophat1900. I'm wondering if you could point me to material describing the high insulin levels causing insulin resistance. I'm interested in reading about this. I'm also interested in learning about the effects of K2-mk7. I currently take allopurinol to manage uric acid.

And yes, I've been on a carb controlled diet for a low time but experienced ever increasing meds (metformin) over the last 15 years. Just looking to keep things under control.
Stay safe.

@Brunneria has already mentioned one great source in Jason fung. He has also published a book called "The diabetes code." I haven't read it myself, but many people on here swear by it.

Here's some more info on Dr.Fung's https://www.dietdoctor.com/health/insulin-resistance

The dietdoctor site has a huge amount of info on a lot of things diabetic related, so worth checking out. Also there are a lot of podcasts talking about the subject. Ivor Cummin's https://thefatemperor.com/blog/ His blog has interviews with some top specialist in the fields of diabetes, diet, cholesterol, heart disease and contains a great amount of info I have found very useful. You may find subjects there that are of interest.

We all seem to have a fair amount of time on our hands at the moment to read and watch podcasts, so I thought it worthwhile. You could also google Dr.Ben Bikman on insulin, he does a lot of youtube presentations.

The graphic below is often shown on low carb, keto diet sites and is a basis image of how the cycle goes with insulin resistance, but there is a ton of info out there in googleland as well. Hope this is useful for you.