I want a scientific explanation for this case

[ibra_lab_76]

my friend his age 32 yaer enter hospital comlaining fromdehydration and diarrehea his BP140/90 AND rbs:410mg/dl,HBAIC11.88% THEY ADMIT HIM AND GAVE HIM 10UNIT INSULIN,glucphage ,amyral then discharge after 1 day he took glucophage ,amyral and fallow adiet progarm for one month then repeat the test his FBS:108mg/dl,andHBAIC5.05% since my frined not complain from any anemic case and his kidney function test normal my guestion if there any scientific answer for thr reason of decrasing his HBAICfrom11.88 to5.05 within only one month best regard

 

[borofergie]

my friend his age 32 yaer enter hospital comlaining fromdehydration and diarrehea his BP140/90 AND rbs:410mg/dl,HBAIC11.88% THEY ADMIT HIM AND GAVE HIM 10UNIT INSULIN,glucphage ,amyral then discharge after 1 day he took glucophage ,amyral and fallow adiet progarm for one month then repeat the test his FBS:108mg/dl,andHBAIC5.05% since my frined not complain from any anemic case and his kidney function test normal my guestion if there any scientific answer for thr reason of decrasing his HBAICfrom11.88 to5.05 within only one month best regard

Well, on the surface, it sounds like he is a diabetic that has repsonded well to treatment.

Having said that - a drop from 11.95% to 5.1% seems a little implausable. Most people's red blood cells live for longer than a month (about 3 months in general), so it is unlikely that he would have replaced all of the damaged red blood cells from his first test, which would allow him to get a nearly perfect second test. It's not impossible though - some people turn over blood cells more quickly.

Was he diagnosed as a diabetic before he went into hospital with dehydration?

I'm suspicious that one of the two HbA1c tests was wrong.

 

[AMBrennan]

Most people's red blood cells live for longer than a month (about 3 months in general), so it is unlikely that he would have replaced all of the damaged red blood cells from his first test,

So, you're saying that a moving average cannot possibly decrease? Seems legit :crazy: [e.g. 20, 5, 5, 5; 3 months moving averages are 10, 5]

 

[borofergie]

Most people's red blood cells live for longer than a month (about 3 months in general), so it is unlikely that he would have replaced all of the damaged red blood cells from his first test,

So, you're saying that a moving average cannot possibly decrease? Seems legit :crazy: [e.g. 20, 5, 5, 5; 3 months moving averages are 10, 5]

No - I'm saying that it's unlikely that he could turn over enough blood cells. Of course the average can decrease, but not by that much when the first 2 months of the averaging period were at extremely hight BG levels.

HbA1c 11.88% corresponds to an average BG of 16.4 mM
HbA1c 5.05 corresponds to an average BG of 5.5 mM

If his BG was @16.4 mM for the first 2 months of the 3 month averaging period, the average over the whole 3 months can't possibly be 5.5mM...

Even if his BG was at a "normal" 4.5mmol for the whole of month 3, the average would be 12.4mM (which is equivalent to a HbA1c of 9.5%).

12.4=(16.4+16.4+4.5)/3

Of course, HbA1c isn't a true three month average, and it's supposed to be heavily biased towards the last 6 weeks, but even then, I think there is likely to be enough residual glycated blood cells from his hyperglycemic period to make a HbA1c of 5% kinda unlikely.

Capiche?

 

[Daibell]

Hi. I hope he is being referred to his GP or Diabetes clinic for ongoing diagnosis and treatment? I also hope the diet he was given wasn't the standard NHS 'have plenty of carbs' mantra? Have a read of the diet approach diabetics need on this website and follow these in conjunction with ongoing medication from a doctor.