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Insulin resistance
- Thread starter HICHAM_T2
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Bluetit1802
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I'm sorry, but I don't really understand your question! Are you asking if insulin resistance exists?
HICHAM_T2
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Hi Madam and welcome back
I mean maybe the problem will be in the genetic composition of insulin The evidence is that cells respond to insulin used externally Why not resist even external insulin Someday we will discover that this word is incorrect
JohnEGreen
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A rose by any name is still a rose.
It's a physiological condition that can be demonstrated not an abstract conception.
It's a physiological condition that can be demonstrated not an abstract conception.
HICHAM_T2
Well-Known Member
Well suppose we took insulin from a healthy person to an infected person will remain resistant to insulin I think the resistance will disappear
Rokaab
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As far as I know it's not the insulin that is at fault, its the resistance of your body to said insulin, T2's on insulin don't respond better to the injected insulin than their insulin it's just they have a lot more of it in their system (ie. their own and the injected) and because there is more insulin it can bring the sugar levels down, though it will not help their insulin resistance. Note: I may be wrong but I reckon I might be right
Guzzler
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As far as I know it's not the insulin that is at fault, its the resistance of your body to said insulin, T2's on insulin don't respond better to the injected insulin than their insulin it's just they have a lot more of it in their system (ie. their own and the injected) and because there is more insulin it can bring the sugar levels down, though it will not help their insulin resistance. Note: I may be wrong but I reckon I might be right
Can't see anything wrong with that.
Alexandra100
Well-Known Member
Agreed. As far as I know, most/all T2s have developed insulin resistance (so tend to be over-weight) and most/all T1s produce no/not enough insulin (so tend to be under-weight). However, in T2s the pancreas can get exhausted by producing more and more insulin to try and overcome severe resistance, so the T2 develops T1 and needs artificial insulin. In T1s, injecting lots of insulin can lead to insulin resistance, so the T1 develops T2 (maybe gains weight) and needs even more injected insulin. Both conditions are known as "double diabetes". Apologies for unscientific résumé. If I have got this wrong, I hope someone will instruct me better.
Nope, not true. Being overweight for whatever reason doesn't protect you from a failing immune system. In adults getting T1 (LADA) the condition usually develops much slower than in children. People with late onset T1 are often misdiagnosed, sometimes for years. Being overweight and over 30 or so is a big risk factor for misdiagnosis, as HCP's often think type1's are skinny...
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HICHAM_T2
Well-Known Member
Did you mean that the patient's body did not respond even if we used insulin from a healthy personAs far as I know it's not the insulin that is at fault, its the resistance of your body to said insulin, T2's on insulin don't respond better to the injected insulin than their insulin it's just they have a lot more of it in their system (ie. their own and the injected) and because there is more insulin it can bring the sugar levels down, though it will not help their insulin resistance. Note: I may be wrong but I reckon I might be right
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Hi,
Basically (in short.) T1s are "skinny" because of the beta cells are not produciing insulin to deal with the increasing rapid sugar level rise.
This lack of pancreas insulin production causes rapid weight loss as the body needs energy from somewhere, so it burns the body fat stored...
Basically (in short.) T1s are "skinny" because of the beta cells are not produciing insulin to deal with the increasing rapid sugar level rise.
This lack of pancreas insulin production causes rapid weight loss as the body needs energy from somewhere, so it burns the body fat stored...
Rokaab
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Yes that's what I think
HICHAM_T2
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So far I have nothing to prove the contrary
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Hi @HICHAM_T2 my friend.
One could transplant a whole new heathy pancreas into a patient with insulin resistance. It would not solve the issue..
The "tactic" is using more insulin (with injecting for T2.) than is naturally produced, to "ramp up" the message to the receptors.?
Right. Except in adults, where beta cells die slowly. So they still produce enough insulin to store fat and to not develop ketoacidocis, but not enough to keep bg in a normal range. Rapid weight loss is one of the important reasons to check for T1, but T1 is happy to occur without it. And mind, half or so of newly diagnosed T1's are adult and thus at risk of misdiagnosis by GP's and other HCP's who've learned that T1 is a childhood disease and comes with weightloss.
Alexandra100
Well-Known Member
I certainly didn't mean to say that being over-weight protects anyone from a failing immune system. I was trying to say that a majority of T2s suffer from insulin resistance which tends to lead to weight gain. Is this not correct? I have seen 20% mentioned as the proportion of skinny T2s.
I am myself a skinny query pre-T2 / LADA and I do realise that the stereotypes often lead to mis-diagnosis. It would be hard to frequent this Forum for long without coming across cases of that.
HICHAM_T2
Well-Known Member
Yes we agree insulin deficiency is the cause of thinness and The production of insulin is the cause of obesity
But why not be the reason the Insulin lose his insulin class i m sorry for my english i hope to understand me
Sounds right to me. But you proceeded to state that most/all T1's tend to be underweight. Therefore my reaction, nothing to do with your statements about T2
Alexandra100
Well-Known Member
According to Jenny Ruhl, there are skinny T2s and also skinny / plump LADAs. As far as I can see, the only difference between them is that the LADAs tend to deteriorate gradually, whereas with proper diet the T2s may not. Depressingly, she says that both are hard to manage because of the lack of insulin. As far as I can learn, the only way to help one's beta cells is to keep one's bg low, whereas there are multiple strategies which may reduce insulin resistance.
Insulin resistant T2's need a lot more of the same injected insulin as non-insulin resistant T1's. I think that proves that it's not something wtrong with the insulin, but with the way their bodies use it.
