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- Type of diabetes
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- Insulin
10 units of Afrezza works like about 3 units of apidra/novorapid.
One "unit" for each insulin analog are actually completely different quantities by weight. Delivery method also makes a huge difference.
We've posted on our blog that Afrezza's labelling of "4u" and "8u" is very confusing. In terms of total insulin exposure in the blood (AUC) , Afrezza 8u is about the same as 4u. Afrezza 8u is less than 2u.
We made this video trying to explain what this means in practice:
http://afrezzadownunder.com/2015/09/afrezza-units-insulincarb-ratios/
However, labelling Afrezza as 1u and 2u would be even more confusing. We think that it should be labelled something completely different, like S, M and L. No prior experience with counting units is helpful when learning Afrezza, so why label it that way?
T1 diabetics require so much more insulin than non-diabetics because the injected insulin lowers blood glucose by telling muscle cells to take more glucose in than they need for immediate energy requirements.
Non-diabetics control glucose primarily with insulin from the pancreas secreted towards the liver, which suspends its glucose output. Very little insulin reaches the muscles in nondiabetics. In fact, insulin is not required for normal muscle operation. Nor is insulin required for normal glucose control if glucagon receptors are blocked (thus suppressing the liver's glucose output)