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Long-term Cure For Type 1 Diabetes??

Discussion in 'Type 1 Diabetes' started by DunePlodder, Jun 21, 2018.

  1. DunePlodder

    DunePlodder Type 1 · Well-Known Member

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  2. LittleGreyCat

    LittleGreyCat Type 2 · Well-Known Member

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    One key thing to note is that it is a US based study.
    In the UK, I had the BCG vaccination; I think that this is still common?

    Ah! https://www.nhs.uk/conditions/vaccinations/bcg-tb-vaccine-questions-answers/.
    also
    which makes me wonder why adults don't/didn't get a booster. I was done as a teenager at school (assume aged 15) so I should have had a booster at 30 and 45 to maintain my immunity if the vaccine only lasts 15 years.

    However prior to 2005 there must have been T1s in the UK who had the BCG vaccination without being cured of diabetes, although I also note that
    so even if there was a response nobody would have tied it in with a vaccination taken 3 years ago.

    If I was cynical I might think that this research was part of trying BCG on everything from piles to ingrowing toenails to the common cold because widespread use seems to be eliminating TB from many countries which are then stopping mass vaccinations. An indication that the vaccination is so good that it is destroying not only TB but its own market.

    Still, if this is anywhere near accurate then it could be a big result for T1s and presumably also for at least some T2s.
     
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  3. smc4761

    smc4761 Type 1 · Well-Known Member

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  4. kev-w

    kev-w Type 1 · Well-Known Member

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    Quack quack :)
     
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  5. NicoleC1971

    NicoleC1971 Type 1 · Well-Known Member

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    Thanks for posting this and it does look hopeful. To note that this is a small study but is in humans not mice and is to be expanded. The article mentions work in Italy and Australia with reference to other autoimmune diseases such as MS and food allergy. Both these countries use bcg so I am guessing the treatment is hypothesised to work even if the patients have been exposed to the TB virus via vaccination.
    I am a type 1 and did get a bcg 3 years into my diagnosis. Not cured but totally up for a life with less endogenous insulin. BTW it bugs me that whilst I share the opinion that type 2 diabetes drugs represent huge profit vehicles for big pharma, it was a big pharma/biotech firm that genetically engineered the insulin I take today. A good thing when you think of the thousands of pigs whose pancreases would need to be mashed to produce what the world needs today.
     
  6. smc4761

    smc4761 Type 1 · Well-Known Member

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    Thank you for your constructive contribution
     
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  7. kev-w

    kev-w Type 1 · Well-Known Member

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    And thanks for your just as constructive reply...
     
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  8. EllieM

    EllieM Type 1 · Well-Known Member

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    http://www.wbur.org/commonhealth/2018/06/21/vaccine-diabetes-bcg-type-1

    Well, according to the above, there were just 9 people in the study, and they are not talking about stopping insulin, just better HbA1C results.... (That's how I'm reading the article, maybe I've misunderstood, happy to be corrected...:))

    I think it's a bit of a quacker.

    Though I had the BCG vaccine in my early teens, maybe that's the reason I'm (relatively) complication free now????
     
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  9. EllieM

    EllieM Type 1 · Well-Known Member

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  10. boboblck

    boboblck Type 1 · Well-Known Member

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    I got BCG at 15 at school in UK, then again a year ago when I was teaching in Italy at the age of 28- doctor came into the school and teachers needed to go up for the vaccine. I have actually been wondering if this triggered my diabetes (type 1) I was diagnosed this Feb but was getting symptoms after the vaccine such as infections etc..

    Any thoughts on it triggering and not curing?
     
  11. Chris Bowsher

    Chris Bowsher Type 1 · Well-Known Member

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    @boboblck I had a BCG around two years before i was diagnosed with T1
     
  12. briped

    briped Type 2 · Well-Known Member

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    "Testing bitter chocolate as a dietary supplement was his idea. When I asked him why, Frank said it was a favorite of the “whole food” fanatics. “Bitter chocolate tastes bad, therefore it must be good for you,” he said. “It’s like a religion.”" :hilarious::hilarious: So true.
     
  13. phoenix

    phoenix Type 1 · Expert

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    The reports of a 'cure' are overenthusiastic since it showed a large reduction in Hba1c, whilst continuing insulin therapy. Denise Faustman is not a quack though (that was an unhelpful comment) Her research has been going on, stage by stage for many years .(there are several posts on here about it, going back many years)
    The latest report seems to be based on 52 subjects. The Telegraph article includes positive comments on the methodology.https://www.telegraph.co.uk/science...erse-type-1-diabetes-almost-undetectable/amp/
    For some background : a video from 10 years ago.
    See also.https://www.diabetesdaily.com/blog/...eversal-trial-seeks-more-participants-383495/

    This report includes some data from the recent results https://www.diabetesdaily.com/blog/breaking-research-bcg-vaccine-reduces-a1c-long-term-579539/
     
    #13 phoenix, Jun 22, 2018 at 9:49 AM
    Last edited: Jun 22, 2018
  14. EllieM

    EllieM Type 1 · Well-Known Member

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    OK, that's fair enough. I think I got irritated by articles claiming that it reversed T1, instead of being a potentially useful aid. And that's the journalists' fault because it makes a better headline. Actually, I think the journalists are quacking.

    I still don't understand why the two articles give different figures for the number of people in the study....
     
  15. tim2000s

    tim2000s Type 1 · Expert
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    Let's be clear what the original study states. It is that those treated with a specific form of BCG in the trials had much lower Hba1Cs. They were not producing more insulin, and a c-peptide test showed that they were not producing c-peptide.

    The mechanism seems to be that the T-Reg white blood cells had changed their energy characteristics to use more glucose and therefore remove more from the body.

    All of the participants in the study continued to use existing technologies including CGMs and pumps, so no insulin was stopped as a result of this therapy.

    All in all it's an indicator of a potential amelioration at this stage, and still a long way from a "cure".
     
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  16. LittleGreyCat

    LittleGreyCat Type 2 · Well-Known Member

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    Darn - lost my original in a botched edit.
    Still, the above really says it all.

    Changes to some cellular metabolic pathways increase the uptake of glucose which seems to make T1 BG control using conventional methods more effective.
     
    #16 LittleGreyCat, Jun 22, 2018 at 11:41 AM
    Last edited: Jun 22, 2018
  17. boboblck

    boboblck Type 1 · Well-Known Member

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    Imagine that’s what triggered it..possibility that I could have avoided it is frustrating
     
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