Prolonged antibiotic use affects gut bacteria and accelerates type 1 diabetes development,...

DCUK NewsBot

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Prolonged use of antibiotics can accelerate the development of type 1 diabetes by disrupting gut bacteria, according to new research. Scientists at the University of British Columbia demonstrated that mice that were susceptible to diabetes had more harmful and less beneficial bacteria than those not at risk of the condition. They report that long-term and over-use of antibiotics disrupts these bacteria and plays a role in the development of type 1 diabetes. Antibiotics exposure In their study of non-obese diabetic (NOD) mice, published in Nature Group's ISME Journal, the researchers conducted two manipulations of gut microbes. In the first experiment, they transplanted NOD microbes into non-obese resistant (NOR) mice. This induced insulitis in the NOR mice, suggesting that the NOD microbiome is capable of producing diabetes. In the second experiment, the researchers exposed the mice to antibiotics and evaluated their intestinal microbiota. They discovered that the antibiotics led to accelerated diabetes onset and increased T-helper type 1 (Th1) and reduced Th17 cells in the intestinal lymphoid tissues. In other words, the harmful bacteria generated an immune response which led to the stimulated destruction of insulin-producing cells. "We were able to establish a clear relationship between bacteria, the body's immune reaction and the development of type 1 diabetes," said senior author Professor Deanna Gibson. "This is likely to have significant implications for treatment of the disease. The next steps are to narrow-in and identify which bacteria induce or perhaps protect against type 1 diabetes. This, in turn, could help with the production of more specific antibiotics." Role of bacteria The researchers concluded that bacteria has a significant role within the development of type 1 diabetes, and antibiotic use can alter the normal development of the gut and affect people's health. "While it's clear that antibiotics are very useful in medicine, overusing them can have significant consequences," added Gibson. Earlier this month, another study highlighted the danger of increased antibiotic consumption. Scientists at Athens University Medical School warned that young children who are given antibiotics are more likely to develop prediabetes in adolescence, and urged that antibiotics should be administered only when really necessary.

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Indy51

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Type of diabetes
Type 2
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Diet only
The study of the microbiome keeps coming up with more and more problems caused by its disruption. I've been hearing lately about increased risk of so many things (including risk of Type 1) as the result of C-sections replacing the mother's vaginal microbiome on the child's skin with microbes from the birth environment; disruption of the gut by feeding formula instead of breast feeding; antibiotics and so on.

@admin - it might be an interesting topic of research among our Type 1 members - how many were born by C-section; how many not breast fed; how many with repeated childhood antibiotics?
 

KevinPotts

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2,606
Type of diabetes
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Unkind people, failure to take personal responsibility.
The study of the microbiome keeps coming up with more and more problems caused by its disruption. I've been hearing lately about increased risk of so many things (including risk of Type 1) as the result of C-sections replacing the mother's vaginal microbiome on the child's skin with microbes from the birth environment; disruption of the gut by feeding formula instead of breast feeding; antibiotics and so on.

@admin - it might be an interesting topic of research among our Type 1 members - how many were born by C-section; how many not breast fed; how many with repeated childhood antibiotics?

I learn something new everyday and you insightful little comment is a new piece of info I new nothing about. Thanks:)!


Diagnosed 13/4/16: T2, no meds, HbA1c 53, FBG 12.6, Trigs 3.6, HDL .75, LDL 4.0, BP 169/95, BPM 85, 13st 8lbs, waist 34" (2012 - 17st 7lbs, w 42").

16/6/16: FBG AV 4.6, Trigs 1.5, HDL 2.0, LDL 3.0, BP 112/68, BPM 6O, 11st 5lbs, waist 30", PWV 7.0. Lifelong migraines and hay fever gone.

Regime: 20g LCHF, run 1 mile daily, weekly fasting, occasionally longer fasts.
 

azure

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Type 1
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I've read a lot about this over the past few years - the role of the gut in Type 1. I'm no medic and no scientist, but I strongly believe that the gut plays an important part in the development of Type 1.

Things like breastfeeding are linked to that. That wa the one thing my consultant told me to do when I asked what I could do to reduce my children's risk of Type 1.