Question for Tresiba users

Levy

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312
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Type 1
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Hi all, I'll be starting on Tresiba today or tomorrow. It's the first time in years I've had a basal that I only take once a day (I'm currently on 2x Levemir) and I was just wondering for those who are using it as well - does it matter whether I take it in the morning or at night in your experience? I know it's ultra long acting and so it probably shouldn't matter, but I know packet descriptions and peoples' experiences sometimes don't exactly match so I thought I'd ask.

My mornings are much more regular than my evenings, so I'd be able to take it at the same time more easily in the mornings. But I don't know if people are finding it more stable/better if they take it in the evening?
 

Juicyj

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Hi Levy - I was using Tresiba before the pump, I took my injection in the morning, as you've said it makes no difference when you take it. as it lasts up to 36 hours, even if you miss your dose and then take it later in the day it hardly affects your control :)
 
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Levy

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Hi Levy - I was using Tresiba before the pump, I took my injection in the morning, as you've said it makes no difference when you take it. as it lasts up to 36 hours, even if you miss your dose and then take it later in the day it hardly affects your control :)

Perfect, thanks so much!
 

Levy

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Although @Juicyj has answered your question thoroughly, I'll tag a few more Tresiba users and maybe they can share their experiences too:)

@mahola, @robert72, @TorqPenderloin

Thank you very much! Always good to hear about experiences or any tips others might have with changing over :)

I was on 24 total units of Levemir (12u in the morning and 12u at night) and have been started on a single dose of 22u Tresiba. Would be good to know what others experienced when it comes to their dosage of Tresiba vs Levemir!

PS - I am using Libre so will be able to get a good idea of how it's working for me!
 
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Juicyj

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Hi @Levy The only other advice I can offer is to expect some tweaking, it does take a few weeks to settle in and make adjustments, , it's best not to make any adjustments within 3-4 days of the last one as it takes a few days to see the dose settle in, I can remember being disappointed after a couple of weeks thinking it's still not working, it took me a month or 2 to really get the best out of it with the adjustments.
 

Levy

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Hi @Levy The only other advice I can offer is to expect some tweaking, it does take a few weeks to settle in and make adjustments, , it's best not to make any adjustments within 3-4 days of the last one as it takes a few days to see the dose settle in, I can remember being disappointed after a couple of weeks thinking it's still not working, it took me a month or 2 to really get the best out of it with the adjustments.

Thank you, that makes sense! I only got one 'trial' pack from the hospital (I think it's got 5 prefilled pens in it) so hopefully that'll give me enough time to sort it out.
 

kaylz91

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I've only used tresiba but I've never had any problems with it, I'm not a year in yet I was started on 8 units, now down to 5 and looking at a possible further reduction, as mentioned changes are best done after 3 days as it lasts so long, I take mine at 10pm x
 
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I switched to Tresiba 3 months ago (was on Lantus before). I second Juicyj here as this point is crucial: it may took u few days to settle in; so, don't jump doses quickly.

Another point, although Tresiba action profile lasts around 36 hrs, try to stick ~ 24 hrs in order to keep it steady.
 
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sweetbloodsher

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Hi all, I'll be starting on Tresiba today or tomorrow. It's the first time in years I've had a basal that I only take once a day (I'm currently on 2x Levemir) and I was just wondering for those who are using it as well - does it matter whether I take it in the morning or at night in your experience? I know it's ultra long acting and so it probably shouldn't matter, but I know packet descriptions and peoples' experiences sometimes don't exactly match so I thought I'd ask.

My mornings are much more regular than my evenings, so I'd be able to take it at the same time more easily in the mornings. But I don't know if people are finding it more stable/better if they take it in the evening?
Funny you should bring this up. Been on Tresiba for a few weeks (accidentally, b/c I forgot it was Toujeo I'd taken before; duh) to try to cut down on hypo's. Tried it at night, switched back to morning (same as you, it's easier to remember--also read that it peaks @ nine hours). I'm not happy with the results. Even cut down (gradually) from 26 to 20 units. Still going low around 5 AM--after 21 hrs. Very frustrating. Dr. is warning that excessive hypo's have been shown (recently?) to trigger early onset dementia (!!!!). Always something.
 

steve_p6

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Funny you should bring this up. Been on Tresiba for a few weeks (accidentally, b/c I forgot it was Toujeo I'd taken before; duh) to try to cut down on hypo's. Tried it at night, switched back to morning (same as you, it's easier to remember--also read that it peaks @ nine hours). I'm not happy with the results. Even cut down (gradually) from 26 to 20 units. Still going low around 5 AM--after 21 hrs. Very frustrating. Dr. is warning that excessive hypo's have been shown (recently?) to trigger early onset dementia (!!!!). Always something.
Try splitting the Tresiba between morning and evening, I found it reduced my early morning lows.
 
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Jason_Avoneg

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Tresiba is eerily unnoticeable/linear while some of the others have a peak...so it'll feel like it's not doing a lot at first. Also remember given its longer duration you'll most likely find you're using more compared to whatever you were using.

I was convinced my Tresiba is bunk, but my Libre Freestyle suggests not...as I can see its effects when I over do it...

Most importantly I think the benefit of it is it's linear profile, I've found hypos are pretty much nonexistent with it, at least for me.
 
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yakudueye1

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Take it when you are can easily take it if its on the morning make sure its all the time in the morning and at the same time time and its works better than the levemir it did wonders for my yo yo sugars but i had some sensitivity of which meant i had to stop it
 
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Kbarbaracollins_

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Funny you should bring this up. Been on Tresiba for a few weeks (accidentally, b/c I forgot it was Toujeo I'd taken before; duh) to try to cut down on hypo's. Tried it at night, switched back to morning (same as you, it's easier to remember--also read that it peaks @ nine hours). I'm not happy with the results. Even cut down (gradually) from 26 to 20 units. Still going low around 5 AM--after 21 hrs. Very frustrating. Dr. is warning that excessive hypo's have been shown (recently?) to trigger early onset dementia (!!!!). Always something.
 

Kbarbaracollins_

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Messages
49
Type of diabetes
Type 1

I'm on Tresiba and split my dose morning and evening as recommended by Dr Bernstein. My diabetes specialist doesn't think this should be necessary, but Bernstein does it with all his patients.
It does give me a very level basal level especially at night
 

EllsKBells

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362
Type of diabetes
Type 1
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Insulin
@sweetbloodsher you may find you have to bring it down more - I went from 47 units of levemir to 19 of tresiba

Personally, I wouldn't split tresiba. It's really very stable, apart from a slight peak at 9 hours, so if you split it you are effectively introducing more instability, adding in that second peak. I suppose it does also depend a bit on the size of your dose, though - there is no way 47 units would be going in at once!
 

Levy

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312
Type of diabetes
Type 1
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Insulin
Thanks for your replies everyone! I'm currently on day 3 and noticed that my dose definitely needs tweaking (as expected). Interestingly, so far I haven't had DP since starting it where I would normally start rising quite sharply around 7am! Hoping that will last. Libre is definitely a godsend for this changeover, so much easier to see exactly what is happening!
 
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22nw22

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378
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Type 1
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I get lows often I think and I am on Tresiba.
 

Lynne211

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I'm on Tresiba and split my dose morning and evening as recommended by Dr Bernstein. My diabetes specialist doesn't think this should be necessary, but Bernstein does it with all his patients.
It does give me a very level basal level especially at night
I seriously cannot believe a type 1 would listen to Birenstein. Also, YOU'RE NOT SUPPOSED TO SPLIT THE DOSE. The entire purpose of switching to Tresiba is it lasts for nearly 40 hours. WHAT THE HECK IS THE POINT IN SPLITTING THE DOSE, YOU'RE MESSING WITH THE ENTIRE FUNCTION MECHANICS OF THE DRUG. smh
 

Lynne211

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@sweetbloodsher you may find you have to bring it down more - I went from 47 units of levemir to 19 of tresiba

Personally, I wouldn't split tresiba. It's really very stable, apart from a slight peak at 9 hours, so if you split it you are effectively introducing more instability, adding in that second peak. I suppose it does also depend a bit on the size of your dose, though - there is no way 47 units would be going in at once!
SO HOW DOES THIS EVEN MAKE SENSE. No one I know cuts back that much switching from two different basals. And, the fact is Levemir is STRONGER than Tresiba (obviously...that's why Tresiba lasts so long). Levemir is stronger but doesn't last long enough, Tresiba is not so strong because it lasts so long. So, your post makes very little sense and there is NO PEAK with Tresiba, there can't possible be a peak, it's totally flat. there are a million 'other reasons' ones BGs could be 'peaking'.' I also don't know ANY TYPE 1'S, UNLESS VERY OVERWEIGHT WHOM TAKE 47 UNITS OF BASAL OF ANY KIND.