Repaglinide = increase in blood sugar readings???

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Newbat

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I am currently trying out increasing doses of Repaglinide before my meals for Type 2 diabetes. I started at 1mg half hour before breakfast and have now increased by 1mg increments to 4mg. I'm keeping a record of my blood sugar readings 2 hours after the meal but the recordings are showing an INCREASE in my measurements - average = 9.5 on 1mg as opposed to 14.0 on 4mg. Can anybody shed some light on this please? I've trawled the internet but no joy. My medication comprises Metformin and Pioglitazone plus assorted blood pressure/atrial fibrilation medication.
 
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hanadr

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I looked and can't find any interaction warnings for your combination of medicines.
Have you changed your eating pattern?
 
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Dennis

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Hi Newbat,

Comparisons like you are doing will only work if at each meal you have had identical quantities and types of carbohydrates. Your blood sugar level is a representation of what you have eaten. It will vary from meal to meal unless you have identical meals and an identical amount of exercise every day.
 
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Trinkwasser

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Check your 1 hour numbers (or whenever you peak which will probably not be that far off the hour mark), it's possible you are getting sent low and rebounding
 
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Newbat

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Many thanks for these replies.
hanadr and Dennis - My breakfasts are always similar - bowl of muisli/bran flakes plus dried fiuit, skimmed milk and sweetner.
Trinkwasser - Yes, I will check 1hr after breakfast as well. It could be so. I'll do that tomorrow and let you know.
 
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Trinkwasser

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Yes that breakfast is carbs carbs and more carbs which could do it.

My best breakfasts are high protein moderate fat and low carb, usually smoked salmon or some other form of fish (or bacon, or other meat) with a couple of buttered oatcakes and a load of salad including a couple of olives.

Some other suggestions

http://loraldiabetes.blogspot.com/2006/ ... fasts.html

often we are most carb intolerant in the morning, this may vary. For example I can do about three times as many carbs as him at breakfast provided they are oatcakes but he can do about twice as much as me in the evening.

Tuning your diet may work, or it's possible that you are just not suited to this particular drug - nothing works for everyone.
 
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Newbat

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Thanks trinkwasser for your latest info - but I HATE salad. Also, I've now checked my readings after 1hr and 2hrs following breakfast and there's no significant difference in the 2. My diabetic nurse is pretty well saying it's down to insulin now. Oh well.
 
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cugila

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Repaglinide.

Contrary to what has been said previously there are a number of specific interactions between other drugs that can cause the hypoglycaemic effect of the drug Repaglinide to be enhanced.
There are other drugs that can give the opposite effect, i.e. Hyperglycaemic effect. (BNF)

Without knowing all the other medication that you are on you need to discuss this with your GP.

Ken.
 
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Trinkwasser

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Good point, there's a medication interraction checker here

http://www.drugs.com/

that may be useful.

Probably everyone has some drugs that give anomalous responses and every drug has some patients who react badly to it. What the doctors and medical sites often don't take into account is that although a side effect may only occur in 0.05% of patients, if *you* are one of them then 100% of you is affected <G>
 
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