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SGLT2 Inhibitors

R

RachelGrimwood

Member
Messages
10
Type of diabetes
Type 2
Has anyone tried sglt2 inhibitors? I have reduced my hb1ca to 8.2 , previously 10 and 11 at its worst after a long period of denial. In the zone now but looking at alternative medication. Currently on sitagliptin and gliclazide.
 
RachelGrimwood said:
Has anyone tried sglt2 inhibitors? I have reduced my hb1ca to 8.2 , previously 10 and 11 at its worst after a long period of denial. In the zone now but looking at alternative medication. Currently on sitagliptin and gliclazide.
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Has your doctor suggested these? Changing drugs is a discussion with your doctors as if NHS, there is a whole pathway to be followed before being offered

I have used daplaflaglozin but wasn’t happy with the side effects or potential risks so moved to changing my diet and exercise instead.

what are you looking to achieve? There could be other options rather than other drugs
 
Yes, my nurse has suggested these. I am on a low carb diet ( most of the time!) blood sugars are in a good range but I want to lose weight, difficult to exercise too much as I have a bad back.
 
Andydragon said:
Has your doctor suggested these? Changing drugs is a discussion with your doctors as if NHS, there is a whole pathway to be followed before being offered

I have used daplaflaglozin but wasn’t happy with the side effects or potential risks so moved to changing my diet and exercise instead.

what are you looking to achieve? There could be other options rather than other drugs
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Could I ask what side effects and potential risks you had?
 
RachelGrimwood said:
Yes, my nurse has suggested these. I am on a low carb diet ( most of the time!) blood sugars are in a good range but I want to lose weight, difficult to exercise too much as I have a bad back.
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An idea how low carb?

With the drugs you are taking I'd be expecting a far lower HbA1c.

Have you ever had a c-peptide test to look at how much insulin you are producing?
 
I have only been on the low carb for a couple of months so I know my HBA1c will come down further, i use the carb manager app and thus is 18g diabetic carbs a day but I am usually between 12-15g. Yes, I have had the c-peptide test as there was some doubt on whether I was type 2 as both my mum and daughter are type 1, but this has confirmed I am still producing insulin.
 
RachelGrimwood said:
Could I ask what side effects and potential risks you had?
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They did being my levels down and I did lose weight. I took them as my hba1c was 78 and I was about to head to insulin, this was my last chance as far as nhs was concerned before I did the diet changes, goes to show...

anyway: Thrush (very bad but luckily one off but as I said, only on for a month or so) and bad back, plus dizziness
https://www.diabetes.co.uk/diabetes-medication/sglt2-inhibitors.html

I did take them rather than insulin, I acccepted the risks as prolonged high bloods are dangerous too, but the risks instigated other changes so in that respect glad I took them... risks include DKA and gangrene. The nhs letter I got about the former put me off, was similar to this:
https://www.oxfordshireccg.nhs.uk/p...29/primary-care-SGLT2i-alert-january-2020.pdf

I am sure many take and do not have bad issues, but you need to be aware these are not a take and forget pill, it may well work for you, but just as with all drugs be aware
 
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RachelGrimwood said:
Thank you, that’s really helpful.
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I don’t want to put anyone off, I'm the one who often defends Metformin for example. There are many options, but research and owning your own health is important

If you need support whilst making other changed via drugs or you need drugs in general, well that’s your choice

good luck anyway!
 
Hi, the reason why you have been advised to take inhibitors is mainly because your insulin response is not good because of insulin resistance which is common in T2s.
The inhibitors will supplement the insulin required to offset the higher blood glucose levels.
I take sitagliptin 100mg. And so far no side effects.

You may in the future want to reduce the dosage or stop taking it if your Hba1c and fasting levels are near normal, this will happen if you get the balance right for you and reduce the carbs sufficiently. But please talk to your doctor, not the dsn.

Stay safe.
 
Lamont D said:
Hi, the reason why you have been advised to take inhibitors is mainly because your insulin response is not good because of insulin resistance which is common in T2s.
The inhibitors will supplement the insulin required to offset the higher blood glucose levels.
I take sitagliptin 100mg. And so far no side effects.

You may in the future want to reduce the dosage or stop taking it if your Hba1c and fasting levels are near normal, this will happen if you get the balance right for you and reduce the carbs sufficiently. But please talk to your doctor, not the dsn.

Stay safe.
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Thank you, I have reduced the gliclazide to 40mg a day and hope to drop that one completely in the next few weeks. I was just interested to see if the side effects for the inhibitors had affected anyone significantly.
 
RachelGrimwood said:
Has anyone tried sglt2 inhibitors? I have reduced my hb1ca to 8.2 , previously 10 and 11 at its worst after a long period of denial. In the zone now but looking at alternative medication. Currently on sitagliptin and gliclazide.
Click to expand...
i tried experimenting with SGLT inhibitors(made no big difference since i am on a LCHF diet) ,some suggested they almost work like a LC diet cause most of the glucose you eat end up in the urine. But its bad for the kidneys and in some cases(few) caused kidney damage and almost always cause urinary tract infection depending on the amount of glucose you eat.

My suggestion from experience is with a LC diet you wont even need SGLT inh drugs and avoid the risk that come with every drug or just drug dependency
all the best
 
RachelGrimwood said:
I have only been on the low carb for a couple of months so I know my HBA1c will come down further, i use the carb manager app and thus is 18g diabetic carbs a day but I am usually between 12-15g. Yes, I have had the c-peptide test as there was some doubt on whether I was type 2 as both my mum and daughter are type 1, but this has confirmed I am still producing insulin.
Click to expand...

Keep a very close eye on this... I was in the same boat for 10 years... Classed type 2

Infact Ii was LADA (type 1) producing some insulin

Then I push for another cpetide a year or so ago.. Still producing a tiny bit but so tiny I'm now classed type1

So if there is doubt and there is family history of t1 keep a very close eye on it

Given the chance the NHS may continue pushing more pills and more pills when it's possibly not the right thing

If the NHS has not given you a glucose monitor get one... Even if you only use it a couple of times a week to make sure you glucose levels don't go massively high and not drip
 
Drfarxan said:
i tried experimenting with SGLT inhibitors(made no big difference since i am on a LCHF diet) ,some suggested they almost work like a LC diet cause most of the glucose you eat end up in the urine. But its bad for the kidneys and in some cases(few) caused kidney damage and almost always cause urinary tract infection depending on the amount of glucose you eat.

My suggestion from experience is with a LC diet you wont even need SGLT inh drugs and avoid the risk that come with every drug or just drug dependency
all the best
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Unless you are having problems with chronic UTI, the studies show SGLT inhibitors are protective of the kidneys. FWIW I've been on them for a couple years and haver not had any side effects other than some initial weight loss. I know that's just one data point.
 
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