I am a huge fan of ALA, and I really notice the difference if I take it or not, regarding the neuropathy in my feet playing up (ie feeling internal burning sensations). I don't even need R-ALA apparently, for it to work wonderfully. Of all the supplements I have taken since diagnosis, this is the only one that made a real noticeable difference in my physical sensations - that and magnesium supplements to deal with cramping (it did as in I don't get cramping when I take magnesium from time to time.)
Right at the beginning, when I was going off sugar and carbs (gradually over time actually, from moderate carbs to low carbs over about a year), gymnema sylvestre (excuse spelling) and olive leaf extract, eating a lot of cinnamon - helped with sugar withdrawal and clearing candida out of my gut.
I have tried various other supplements, like milk thistle, and who knows if they helped? Because I don't. But above, I know they did, and do. So worth the money and pill popping.