What Is Glucose-responsive Insulin?

[Rabdos]

Hello!

What is Glucose-Responsive Insulin? What's its structure? What's its function?

Thanks!

 

[Lamont D]

This is a type one question.
I have just googled it, as I have never heard of it before.
It is a synthetic insulin, that is designed to control blood sugar levels in T1s.

 

[EllieM]

Hello!

What is Glucose-Responsive Insulin? What's its structure? What's its function?

Thanks!

Smart insulin! It sounds totally awesome. No more hypos!!!! Unfortunately it's still in development....
I hope it's not one of those "cure in ten years" things....

https://www.nasdaq.com/article/novo...-develop-glucose-responsive-insulin-cm1010370

Thank you for posting the question. This product would make a huge difference to my T1 life.

 

[Rabdos]

Thanks, but how it works exactly?

 

[tim2000s]

There are a number of pieces of research looking at "Smart Insulin". Essentially what it does is "coat" the insulin molecules with some form of glucose sensitive material that stops the insulin from working until glucose in the blood reaches a certain concentration, at which point the insulin is released.

You can think of it like a molecular artificial pancreas system. I wrote a little about some of the challenges here: http://www.diabettech.com/jdrf/smar...-what-lessons-can-the-latter-give-the-former/