A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4775822/ edited to include link to another source of same article
In prediabetic NZO mice, an LCHFD was accompanied by reduced blood glucose excursion following food ingestion. However, fasting blood glucose and insulin were elevated, suggesting that this diet caused further impairments in insulin action in these obese and insulin-resistant animals
Any potential benefit of reducing postmeal glucose excursion with such a dietary approach therefore appears to be outweighed by increased weight gain and a requirement for fasting hyperinsulinemia, which may be detrimental to β-cell function. Indeed, there is mounting evidence that initial hypersecretion of insulin in prediabetes contributes to β-cell stress and failure.47, 48 Therefore, rather than being beneficial, an LCHFD may ultimately contribute to faster decline in β-cell function.
...........A decline in β-cell function is primarily responsible for progressive worsening of blood glucose control in type 2 diabetes ………….
This is a mouse study. It is hard to find accurate human studies of LCHF related to T2 as it is not easy to ensure any trial participants were eating an exactly compiled diet. Mice have to eat what they are given!
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4775822/ edited to include link to another source of same article
In prediabetic NZO mice, an LCHFD was accompanied by reduced blood glucose excursion following food ingestion. However, fasting blood glucose and insulin were elevated, suggesting that this diet caused further impairments in insulin action in these obese and insulin-resistant animals
Any potential benefit of reducing postmeal glucose excursion with such a dietary approach therefore appears to be outweighed by increased weight gain and a requirement for fasting hyperinsulinemia, which may be detrimental to β-cell function. Indeed, there is mounting evidence that initial hypersecretion of insulin in prediabetes contributes to β-cell stress and failure.47, 48 Therefore, rather than being beneficial, an LCHFD may ultimately contribute to faster decline in β-cell function.
...........A decline in β-cell function is primarily responsible for progressive worsening of blood glucose control in type 2 diabetes ………….
This is a mouse study. It is hard to find accurate human studies of LCHF related to T2 as it is not easy to ensure any trial participants were eating an exactly compiled diet. Mice have to eat what they are given!
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