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why our immune system attack on our own body part ?

C

Chandradev819

Well-Known Member
Messages
107
Location
Bangalore
Type of diabetes
Type 1
Treatment type
Insulin
Hi Everyone,

Do you know "why our immune system attack on our own body part" ? I asked this question with my doctor, but he didn't give the answer of this.
 
Chandradev819 said:
Hi Everyone,

Do you know "why our immune system attack on our own body part" ? I asked this question with my doctor, but he didn't give the answer of this.
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Bad luck.... That seems to be the answer at the moment.
 
Hi @Chandradev819 - there isn't a clear answer on this, there are lots of theories on why the attack starts but no clear definitive answer, some suggest it can be triggered by illness or a virus, others ideas suggest a lack of vitamin d, living in a sterile environment etc. It's worth having a look round the forum as this topic has been discussed lots of times ;)
 
According to my history, There are no one diabetic person in my family. Last year i was working in night shift. I was not getting good sleep in day time. Then after 9 months i lost my weight 15 kg. But my life was normal.
Then some of friends suggested you take more dairy and bakery product to gain weight like us. Then i started to eat so much sweet and junk food to gain the weight. Finally i went to hospital for normal body checkup to know the root cause. Then i found that i am suffering from diabetics.

So i think in my life due to drastic change in life style and tried to make my body as machine, my body(supercomputer) started to work abnormal.
 
@Chandradev819 No one knows the cause yet. It was the first question I asked my doctor when I was diagnosed. She said it was "20% genetic, 80% environmental" - that is, you can have the 'diabetes genes' but something in the environment needs to trigger them to cause diabetes.

Possible culprits I have read about are cow's milk, wheat, a virus, a lack of Vitamin D, or a leaky gut caused by poor gut bacteria.
 
mahola said:
None of my family members, maternal or paternal, have/had diabetes. Apart from my paternal grandma who developed type 2 in her 60s after a high dose of steroids. But I have given birth to 2 children. One girl with diabetes, one girl without. For now at least. I didn't get diagnosed until I was 31 so my oldest girl may still develop diabetes Who knows! Just luck of the draw.
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Have you looked at trial net? If you are a parent, child, sibling of a person with T1 they will test you for the antibodies to see if you are at risk of developing - 95% test negative (& if you are worrying about the for now, the test might, hopefully, put your mind at ease) - and if you come back high risk they follow up closely so if type 1 does develop you are put into clinical trials to prolong or preserve beta cell function - http://www.bristol.ac.uk/media-library/sites/clinical-sciences/migrated/documents/factsheet.pdf
 
After a lot of reading, the answer that seemed to make the most sense to me, was that after a particularly tough virus that your body has defeated, it recognizes specific markers of that virus within the pancreas, so it starts building antibodies towards the pancreas and attacking it.

There's no special virus known, and definitely nothing concrete, but this explaination was the most satisfactory to me.
 
tpaz said:
After a lot of reading, the answer that seemed to make the most sense to me, was that after a particularly tough virus that your body has defeated, it recognizes specific markers of that virus within the pancreas, so it starts building antibodies towards the pancreas and attacking it.

There's no special virus known, and definitely nothing concrete, but this explaination was the most satisfactory to me.
Click to expand...
Scientists are looking at a process known as 'molecular mimicry' in autoimmune disease, eg.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266166/
 
Personally after being diagnosed I wanted to know why, I quickly accepted that regardless of why I had to get control and do the best I could at managing this, I have heard many theories and some I can believe others I can't. My personal worry now is that my daughter may develop this, so I would be keen to get her antibodies tested (not sure if she would be though !!)
 
This is my explanation:

The immune system is the world's most advanced spam filter. It's supposed to allow good stuff, and dispose of bad stuff. Like any spam filter, sometimes it gets it wrong, either failing to remove bad things, or accidentally removing good things.

If there were no viruses or bacteria or fungi that tried to attack our bodies, we would not need these kinds of defences. But, it's a dangerous world out there and our bodies need to defend themselves, even though it creates a risk of devastating autoimmune diseases.
 
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