Until long-term safety data are obtained for low-CHO diets, a compromise may be appropriate, with the use of diets with lower CHO and modest protein intake.
Such an approach has been trialled in a small-scale study led by the South-West Clinical Diabetes Research Group.23 Obese type 2 DM patients (
n = 102) were recruited and randomly allocated to follow either a CHO restriction diet or a low-fat diet; 79 completed the 3 month study, with similar attrition rates in each group. Weight loss was greater in the low-CHO group (−3.55 ± 0.63 vs. −0.92 ± 0.40 kg) and cholesterol: HDL-cholesterol ratio improved (−0.48 ± 0.11 vs. −0.10 ± 0.10 kg), despite a diet containing more protein, saturated fat and less fibre. On the basis of this, a two-year randomized controlled study of CHO-restriction versus a prescribed energy deficit diet, in 300 obese type 2 DM patients has been
funded by Diabetes UK. The study is due to report this year, and will provide information regarding the long-term efficacy and any potential side-effects of a low-CHO diet in patients with type 2 DM.
A six-month interim report (abstract only) based on 259 type 2 DM patients revealed greater weight loss in the low-CHO group (−3.77(0.46) vs. −1.34 (0.32),
p < 0.0005) with no deleterious effect on glycaemic control, other risk factors or renal safety.