Do you have any evidence for this (other than Fung). Certainly de novo lipogenesis requires insulin to happen, and it does occur when glucose levels are high. However, is there evidence that someone with NAFLD or AFLD or NASH or maybe just general insulin resistance produces excess lipids? Also where does it store them, since adipose storage requires insulin which also may be subject to IR. I conject here but surely this would provide a simple blood test to detect IR?
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/lipogenesis
Evidence, or proof? I don't have any links to hand. Just a lot of prior research and self-experimentation leading me to lean toward's Fung's hypothesis. It's a very complex subject that will drag this discussion off topic if we delve too deep. But all I will say is that my understanding has evolved a lot over the past year or so, and I'm now of the view that pathological insulin 'resistance' (not
sensitivity as we might discuss in the context of, say, a type 1) is actually just the liver running out of places to store the fat it has made from glucose.
You can test 'IR' with glucose vs. circulating insulin and measure HOMA-IR, but what are we
really measuring? Resistance because the insulin no longer works, or resistance simply because the insulin does work but the liver his running out of places to put the fat and so it
appears not to work? Again, if the insulin no longer works, then the liver shouldn't be able to make fat from glucose. But it does. Maybe it's a little bit of both. There appears to be evidence on both sides. Either way, in my view, the standard gummed-up lock & key paradigm is definitely on shaky ground.
I'm going to end my input there because this is definitely off topic.