Hi. Can we work out an estimated HbA1c based on a rolling average of mmol/l?
So if I get an average mmol/l of 10 mmol/l using a continuous blood glucose monitor, is there a conversion to predict approximately what my 3 month HbA1c will be?
I'm wary of "averages" - the HbA1c counts the actual number of glycated red blood cells, and that number gives you an idea/estimate of where blood glucose levels have generally been over the last 2-3 months. It isn't an average of anything.
I think most CGMs have a sort of "estimated HbA1c" function. However - CGMs are measuring glucose levels in interstitial fluid, and estimating a blood glucose vlaue from that. Then they're extrapolating from that estimate to a forecast HbA1c.
They seem to vary a lot in accuracy, however, which I don't think is surprising. Last time I used a CGM (Libre) it was predicting an Hba1c that was significantly lower than actual HbA1c at the next test - if I remember correctly it was a 32 predicted against a 38 actual. That's over 15% out.
Given that these are normal BG levels and it didn't do too well on those, I did wonder if it might give better accuracy at higher BGs, and be calibrated to work better in those levels.
I did find this small study which used CGM results from non-diabetic people. The blurb says that it was run mainly because CGM manufacturers didn't know what "normal" looked like for newer models.
Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. Although data on glycemic profiles of healthy, nondiabetic individuals exist for older sensors, assessment of glycemic metrics with new-generation ...
pmc.ncbi.nlm.nih.gov