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Bcg Vaccine

Discussion in 'Type 1 Diabetes' started by Circuspony, Jun 22, 2018.

  1. Circuspony

    Circuspony Type 1 · Well-Known Member

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  2. EllieM

    EllieM Type 1 · Well-Known Member

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  3. Fairygodmother

    Fairygodmother Type 1 · Well-Known Member

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  4. Fairygodmother

    Fairygodmother Type 1 · Well-Known Member

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  5. boboblck

    boboblck Type 1 · Well-Known Member

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    Helping and triggering
     
  6. Circuspony

    Circuspony Type 1 · Well-Known Member

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    Good link. I'd like to be on that trial. I've still got some beta cells working so it would be good to see if it could stop / reverse the decline.
     
  7. Juicyj

    Juicyj Type 1 · Moderator
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    Was just reading about this now after someone told me about it - not sure how credible it is though as the research is quite limited and could be skewed by patients taking better care of themselves generally.
     
  8. urbanracer

    urbanracer Type 1 · Moderator
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    Look at the article in the newsbot forum, I've posted a link to the science stuff.

    Tim2000s has also given an excellent summary in one of the other threads that is discussing this.
     
  9. EllieM

    EllieM Type 1 · Well-Known Member

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    Normally they do a double blind trial so that some of the patients have the vaccine and other don't: neither patients or researchers know whether they've had the vaccine or not.... You then compare results between the two groups at the end of the trial. But a too small sample makes the results unreliable anyway.
     
  10. urbanracer

    urbanracer Type 1 · Moderator
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    None of the people taking placebos showed any noticeable improvements which is in itself quite interesting.
     
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  11. LooperCat

    LooperCat Type 1 · Expert

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  12. AllieRainbow

    AllieRainbow Type 2 · Well-Known Member

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    Interestingly, there is some suggestion that there is some kind of bi-directional symbiotic relationship between tuberculosis and diabetes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705893/

    "TB can lead to impaired glucose tolerance (IGT) [29, 30] and new onset diabetes [9, 18, 29]. Generally, IGT normalizes after the TB has been successfully treated, but it remains a significant risk factor for developing type 2 diabetes in the future [31]."

    I found this very interesting as I developed TB myself in my early 30s following a car accident, and realised that the initial infection had lain dormant for around 15 years.

    I had the BCG vaccination, and caught TB when I was around 18, obvious later on from looking at the symptoms I had at the time, but unfortunately masked by the BCG when the doctor did a Mantoux test for TB as a last resort - he didn't think I had it as he then relied on a spit test and the TB was already latent elsewhere in the body, so did not show up. After 8 months of treatment I gained a keen understanding of why it is so hard to get people to comply with the drug regimen, leading to drug resistant TB strains - it made me feel so exhausted I couldn't even make myself a cup of tea, and was wiped out for the length of the treatment - it was only when I was able to stop taking the drugs that I realised that it was the drugs that made me feel so bad.

    I have just read through the side effects of the drug I was taking for the TB and realised that one of the side effects is hyperglycaemia - which pretty much matches my symptoms while taking it. Ironically I said to my husband that this March I felt the same as I did while on the TB treatment, and now I realise that was because I had very high blood sugars in March just before diagnosis...

    I am not suggesting the vaccine is a problem, however the consultant said that it gave herd immunity at best and did not stop people developing TB, it just lessened the chances of catching it. That is probably why they don't routinely vaccinate teenagers now.

    Hmm - food for thought...
     
    #12 AllieRainbow, Jun 24, 2018 at 10:25 AM
    Last edited: Jun 24, 2018
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