I have only just got on my Dexcom, but so far I am on sensor #4, and i have voluntarily removed all 3 previous sensors at the 21 day mark.
I have noticed like clockwork at around day 17 i start to get '???' for hours at a time, and the sensors react VERY slowly to changes in my BS to the point where i notice they miss short spikes entirely. For this reason, although i could go longer, i have removed all at day 21.
Also there is thread floating around that explains exactly what happens during that 2 hour start up window, and its not something i would want to do 3+ times, as it shifts the accuracy of the sensors every time you restart them in addition to the enzyme reaction slowing.
So,
Sensor #1 - 21 Days
Sensor #2 - 21 Days
Sensor #3 - 21 Days
Sensor #4 - 11 Days and counting
EDIT -
It always goes back to numbers, typically it can take a few hours - which is a pain. What do you mean 'egg timer'?