Here is an extract from Dr B's own account. You can read more, including his struggle to publicise his discoveries, here:
http://www.diabetes-book.com/bernstein-life-with-diabetes/
It is well worth reading, especially as this and many other extracts from his book (though unfortunately not the paragraphs about Lantus) are available free on his site. I bought the book and I have never regretted it.
"During my twenties and thirties, the prime of life for most people, many of my body’s systems began to deteriorate. I had excruciatingly painful kidney stones, a stone in a salivary duct, “frozen” shoulders, a progressive deformity of my feet with impaired sensation, and more. I would point these out to my diabetologist (who was then president of the American Diabetes Association), but I was inevitably told, “Don’t worry, it has nothing to do with your diabetes. You’re doing fine.” But I wasn’t doing fine. I now know that most of these problems are commonplace among those whose diabetes is poorly controlled, but then I was forced to accept my condition as “normal.”
By this time I was married. I had gone to college and trained as an engineer. I had small children, and even though I was not much more than a kid myself, I felt like an old man. I had lost the hair on the lower parts of my legs, a sign that I had developed peripheral vascular disease—a complication of diabetes that can eventually lead to amputation.
During a routine exercise stress test, I was diagnosed with cardiomyopathy, which is a replacement of muscle tissue in the heart with fibrous (scar) tissue—a common cause of heart failure and death among those with type 1 diabetes.
Even though I was “doing fine,” I suffered a host of other complications. My vision deteriorated: I suffered night blindness, microaneurysms (ballooning of the blood vessels in my eyes), macular edema (swelling of the central portion of my retinas), and early cataracts. Just lying in bed caused pain in my thighs, due to a common but rarely diagnosed and barely pronounceable diabetic complication called iliotibial band/tensor fascialata syndrome. Putting on a T-shirt was agonizing because of my frozen shoulders.
I had begun testing my urine for protein and found substantial amounts of it, a sign, I had read, of advanced kidney disease. In those days—the middle and late 1960s—the life expectancy of a type 1 diabetic with proteinuria was five years. Back in engineering school, a classmate had told me how his nondiabetic sister had died of kidney disease. Before her death she had ballooned with retained water, and after I discovered my own proteinuria, I began to have nightmares of blowing up like a balloon.
By 1967 I had these and other diabetic complications and clearly appeared chronically ill and prematurely aged. I had three small children, the oldest only six years old, and with good reason was certain I wouldn’t live to see them grown.
At my father’s suggestion, I started working out daily at a local gym. He thought that if I were to engage in vigorous exercise, I might feel better. Perhaps exercise would help my body help itself. I did feel slightly less depressed about my condition—at least I felt I was doing something—but I couldn’t build muscles or get much stronger.
After two years of pumping iron, I remained a 115-pound weakling, no matter how strenuously I worked out. It was at about this time, in 1969, that my wife, a physician, pointed out to me that I had spent much of my life going into, experiencing, or recovering from hypoglycemia, which is a state of excessively low blood sugar. It was usually accompanied by fatigue and headaches, and was caused by the unpredictable action of the large doses of insulin I was taking to cover my high-carbohydrate diet. During such episodes, I became confused and unruly and snapped at people. These frequent hypoglycemic episodes had taken their toll upon my parents, and were taking their toll upon my wife and children. The strain on my family was clearly becoming untenable.
Suddenly, in October of 1969,my life turned around.
I had been the research director of a company that made equipment for hospital laboratories, but recently I had taken a new job as an officer of a housewares corporation. I was still receiving trade journals from my old field, and one day I opened the latest issue of a publication called Lab World. I came upon an advertisement for a new device to help hospital emergency rooms distinguish between unconscious diabetics and unconscious drunks during the night, when laboratories were closed. Knowing that an unconscious person was a diabetic and not drunk could easily help hospital personnel save his life. What I stumbled upon was an ad for a blood sugar meter that would give a reading in 1 minute, using a single drop of blood.
Since I’d been experiencing many blood sugars that were too low, and since the tests I had been performing on my urine were wholly inadequate (sugar that shows up in the urine is already on its way out of the bloodstream), I figured that if I knew what my blood sugars were, perhaps I could catch and correct my hypoglycemic episodes before they made me disoriented and irrational.
I marveled over the instrument. It had a 4-inch galvanometer with a jeweled bearing, weighed 3 pounds, and cost $650. I tried to order one, but the manufacturer wouldn’t sell it to patients, only to doctors and hospitals.
Fortunately, my wife, as I’ve said, was a physician, so I ordered one in her name. I started to measure my blood sugar about 5 times each day, and soon saw that the levels were on a roller coaster. Engineers are accustomed to solving problems mathematically, but you have to have information to work with. You have to know the mechanics of a problem in order to solve it, and now, for the first time, I was gaining insight into the mechanics and mathematics of my disease. What I learned from my frequent testing was that my own blood sugars swung from lows of under 40 mg/dl to highs of over 400 mg/dl about twice daily. A normal blood sugar level is about 85 mg/dl.* Small wonder I was subject to such vast mood swings."