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Insulin deficiency - newly diagnosed
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<blockquote data-quote="oldgreymare" data-source="post: 2390947" data-attributes="member: 20373"><p>I suggest continuing to ask for explanations why his c peptide is lower than normal - possibilities include a) he is LADA heading to T1 due to autoimmune destruction of pancreatic beta cells, b) severe/acute T2 where constant high pancreatic fat and glucose levels can "exhaust" beta cells and damp down insulin production, or c) T3 where other trauma to the pancreas destroys or inhibits insulin production. </p><p></p><p>Aside from a low C peptide, the other diagnostic test for LADA/T1 is an autoimmune antibodies panel, especially GAD65. Pragmatically this means a continuing dependency on insulin, but challenging in the LADA phases where you may still sporadically produce your own insulin. </p><p>An exhausted T2 pancreas is the one that typically responds best to strict low carb/keto diet plus weight loss, better exercise regime - as the body loses toxic glucose and fat levels in the pancreas for some this can eliminate the need for injected insulin or other drugs, provided the regime is maintained. </p><p>I know very little about T3 - pragmatically sounds like the treatment is basically same for T1 and equally is not reversible?</p><p></p><p>That said, insulin resistance can play havoc with the health of non diabetics and any type of diabetics, so worth trying to keep BG levels under control as much as you can manage but please don't guilt trip!</p></blockquote><p></p>
[QUOTE="oldgreymare, post: 2390947, member: 20373"] I suggest continuing to ask for explanations why his c peptide is lower than normal - possibilities include a) he is LADA heading to T1 due to autoimmune destruction of pancreatic beta cells, b) severe/acute T2 where constant high pancreatic fat and glucose levels can "exhaust" beta cells and damp down insulin production, or c) T3 where other trauma to the pancreas destroys or inhibits insulin production. Aside from a low C peptide, the other diagnostic test for LADA/T1 is an autoimmune antibodies panel, especially GAD65. Pragmatically this means a continuing dependency on insulin, but challenging in the LADA phases where you may still sporadically produce your own insulin. An exhausted T2 pancreas is the one that typically responds best to strict low carb/keto diet plus weight loss, better exercise regime - as the body loses toxic glucose and fat levels in the pancreas for some this can eliminate the need for injected insulin or other drugs, provided the regime is maintained. I know very little about T3 - pragmatically sounds like the treatment is basically same for T1 and equally is not reversible? That said, insulin resistance can play havoc with the health of non diabetics and any type of diabetics, so worth trying to keep BG levels under control as much as you can manage but please don't guilt trip! [/QUOTE]
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