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Metformin Good But Bad Side Effects So Trying Berberine

Discussion in 'Alternative Treatments' started by ThePenguinPimp, Jul 27, 2018.

  1. ThePenguinPimp

    ThePenguinPimp Type 1 · Well-Known Member

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    I'm a T1 diabetic (for 30 years) on insulin pump with CGM so have a real time view of what my blood sugars are doing. I have been on a low carb diet for nearly 20 years (the only carbs come from any veg I eat - not potato) and still have suffered with completely erratic blood sugars indicating insulin resistance is still a big problem. I started on metformin about 6 weeks ago and for the first time I can remember actually felt as though I have some control over what is going on! Unfortunately the side effects that come with taking metformin (for me) are unbearable (mainly bad stomach and associated pain/bloating/and the rest) so I am giving berberine a go.

    Just been for my hba1c (which even after just 6 weeks on metformin I expect to be a vast improvement on my last one) and am planning to stop the metformin and start on berberine (tomorrow if the berberine arrives)..

    I also have my cgm uploads to compare weeks on different meds.. lets see how it goes..
     
  2. DCUKMod

    DCUKMod I reversed my Type 2 · Master
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    What a shame you didn't get along with Metformin. Did you try the Extended Release variant, or just the standard version? ER tends to be tummy friendlier.
     
  3. ThePenguinPimp

    ThePenguinPimp Type 1 · Well-Known Member

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    Initially went on normal but after a couple of weeks went onto the slow release which did initially seem better but has got really bad again.. I think my digestive system may have something to do with it as (due to autonomic/internal neuropathy) my whole digestive system is extremely slow and I must take metaclopramide to get my stomach to even empty.. I guess I know I've got metformin to fall back on if the berberine does not work but am really hoping this will have an effect..
     
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  4. DCUKMod

    DCUKMod I reversed my Type 2 · Master
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    Oh dear. Did you start really slowly? I woner if a really small dose to start with would be OK and a very slow increase. Sometimes it seems the speed of titration makes a realy difference.
     
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  5. ThePenguinPimp

    ThePenguinPimp Type 1 · Well-Known Member

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    No I was so determined I could cope with any side effects I just went straight onto 2000mg a day quick release.. the bad side effects didnt come in til a fortnight later.. when I went onto the slow release the side effects went away at first then came back and have got progressivly worse..

    The one thing I keep telling myself is that I know the metformin works.. so if I don't see good results with the berberine (like studies suggest I might.. I'm still hopeful) I can go back to the metformin and start on a lower dose and work my way back up.. the fact the side effects seem to get worse over time does not fill me with confidence.. but I have seen such great results I am prepared to give it a go.. if the herbs don't work that is!
     
  6. Moggely

    Moggely · Guest

    I would love to know how you get on with berberine I have heard a lot of good things about it.Good luck.
     
  7. DCUKMod

    DCUKMod I reversed my Type 2 · Master
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    Penguin - Metformin works on a cummulative effect, so the first few doses have very little effect indeed. Iy's only when it has built uo in the system that it becomes most effective.

    I wonder if you started in a low dose and didn't increase for a few weeks in between each increase if your system would cope better with it.

    In your shoes, I might be inclinded to give that a go, with the extended release, due to it's usually gentler impact.

    Worth a chat with the medics, perhaps.

    Good luck with the Berberine. I know a few folks have tried it over time., but not sure if I recall anyone having game-changing results - although that could just be my memory.

    I'l never taken Metformin or Berberine, so have no personal experience. I think @Brunneria might have given Berberine a go at some stage, but the same goldfish brain rules on my memory apply there too!
     
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  8. ringi

    ringi Type 2 · Well-Known Member

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    I agree, start of half a tablet of slow release per day with a meal, don't increase the dose until you have had a few weeks without the side effects.
     
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  9. DCUKMod

    DCUKMod I reversed my Type 2 · Master
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    As I understand it, ringi, the extended/slow release tablets should not be halved, as doing so has a detrimental impact of their slowed rlease. Again, as I understand it, halving a SR tablet (breaching the coating), pretty much strikes out the ER/SR effect and it becomes very much akin to the standard release.
     
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  10. Alexandra100

    Alexandra100 Prefer not to say · Well-Known Member

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    Did you start with the lowest possible dose, taken with a meal and then build up gradually?

    Sorry, I see this has been covered already.
     
  11. ringi

    ringi Type 2 · Well-Known Member

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    Good point, it will depend on how the the slow release is done, and that may not be the same for all makes.
     
  12. ThePenguinPimp

    ThePenguinPimp Type 1 · Well-Known Member

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    I have reduced to one 1000mg slow release a day and am taking berberine at other times (I have now read a few studies which show they can work well together) and whilst I am still bloated the awful rest of the side effects seem to have mostly stopped. I am going to see how this goes. So far so good!
     
  13. DCUKMod

    DCUKMod I reversed my Type 2 · Master
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    In your shoes, I'd be taking things very slowly indeed.

    Fingers crossed for you!
     
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