Dear Administrator, I was diagnosed of type 2 diabetes in 2006, since then I have been on metformin 500 mg and Daonil 5mg, recently increase to 1000mg but it seen the 1000mg is no longer effective, can I start taking insulin? Or increase the dosage to 1500mg? Now I am feeding hotness in my legs especially the left leg, muscles pain from foot to ankle and neuropathy pains, what should I do to reverse these complications? I am sacred of leg amputation, what should I do to arrest the complications? Kindly get me posted, thanks