Hi Petepontiac,
I need to take Creon (enzyme replacement) with all food (even snacks) as I'm a T3c being treated as a T1. My pancreas is dead or dying, so doesn't produce the enzymes to digest food.
I don't have problems with Creon.
There's some basic info here:
https://www.creon.com/CFPatients/FAQs
Is there anything else you want to know?