Slow acting insulin once a day

[lucylocket61]

You know, I have often wondered if, after several years, despite people doing their very best, some type 2 diabetics lose some of their insulin production?

Just my thoughts, but I do think there are different sub-types of type 2 diabetes, with different causes, reactions to carb levels and who need different treatment pathways.

We are all different, even under the heading of type 2. In my opinion.

 

[EllieM]

You know, I have often wondered if, after several years, despite people doing their very best, some type 2 diabetics lose some of their insulin production?

My understanding (possibly incorrect, this is a very complicated subject and the mechanisms appear to be disputed) is that long term high blood sugars damage beta cells, though this damage can be reversed to some extent by normalising blood sugars. (Unlike autoimmune beta cell destruction in T1s, where when they are gone they are gone.) So long term (eg ten years) T2s can end up with reduced insulin production, at which point insulin may be the best treatment for them. The articles I googled seemed to agree that beta cell decline was a given, though they argue about the mechanisms....

eg
Mechanisms of β-Cell Death in Type 2 Diabetes | Diabetes (diabetesjournals.org)

 

[millenium]

Thank you for all the comments. They are helpful for my analysis on this topic.

 

[Jaylee]

Thank you for all the comments. They are helpful for my analysis on this topic.

Hi,

Why did you ask....
(If I remember, your father is diabetic.)
Are you or you father under discussion regarding prescription of this treatment?

 

[millenium]

Hi,

Why did you ask....
(If I remember, your father is diabetic.)
Are you or you father under discussion regarding prescription of this treatment?

Asking for my uncle who was diagnosed a month ago. I am now helping him.
My father has passed away last year due to a haemorrhagic stroke. That was why I was absent from posting in this forum from that time till recently.

 

[Jaylee]

Asking for my uncle who was diagnosed a month ago. I am now helping him.
My father has passed away last year due to a haemorrhagic stroke. That was why I was absent from posting in this forum from that time till recently.

My condolences for your father.

It a disappointing that more T2s using a basal regime haven't participated in regards to the perspective on how they fare..
I know as a T1, I couldn't manage souly on basal alone. Even as a low carber..there are quite often corrections needed for liver dumps & i don't even do breakfast?

I did a quick google on the statistics of T2s using Exogenous insulin. Not a lot to go on.. Somewhere did mention around 30%???
On a randomness browser search. But I couldn't testiment to how accurate that actually is..

 

[KK123]

You know, I have often wondered if, after several years, despite people doing their very best, some type 2 diabetics lose some of their insulin production?

Just my thoughts, but I do think there are different sub-types of type 2 diabetes, with different causes, reactions to carb levels and who need different treatment pathways.

We are all different, even under the heading of type 2. In my opinion.

That is also the opinion of all the Consultants that I have had conversations with over the years, so you are in good company. One of them actually said there are so many variations across all aspects of diabetes no matter what category they are put into that trying to fit them all under the heading of 'type 1', 'type 2' and 'the rest' which he said was a catch all category, was making many individuals suffer needlessly as a result.

 

[Fenn]

It’s why I’ve had often said, it does not matter what type I am as I think this is me exactly, as it stands, one way or another, my treatment won’t change so for me it doesn’t matter one bit.

 

[millenium]

Hi,

Why did you ask....
(If I remember, your father is diabetic.)
Are you or you father under discussion regarding prescription of this treatment?

From using the information in this site, when my father was alive, his blood glucose level was in a very good range, he never has to worry about his diabetes.

My condolences for your father.

It a disappointing that more T2s using a basal regime haven't participated in regards to the perspective on how they fare..
I know as a T1, I couldn't manage souly on basal alone. Even as a low carber..there are quite often corrections needed for liver dumps & i don't even do breakfast?

I did a quick google on the statistics of T2s using Exogenous insulin. Not a lot to go on.. Somewhere did mention around 30%???
On a randomness browser search. But I couldn't testiment to how accurate that actually is..

My late father has controlled his blood glucose so well after he limit his carb intake that the doctors forgot that he was diabetic. Now it is my uncle that I am helping him to adjust his diet. Also, he has been advised by doctors to take certain medicines that I was previously unaware of for T2. Like insulin and Empagliflozin. From what I see, his diabetic condition is similar to my late father and seems possible to be control on 100g of carb daily without diabetic medication. I am monitoring his upon awaken, and after meals readings at the moment.

 

[millenium]

My condolences for your father.

It a disappointing that more T2s using a basal regime haven't participated in regards to the perspective on how they fare..
I know as a T1, I couldn't manage souly on basal alone. Even as a low carber..there are quite often corrections needed for liver dumps & i don't even do breakfast?

I did a quick google on the statistics of T2s using Exogenous insulin. Not a lot to go on.. Somewhere did mention around 30%???
On a randomness browser search. But I couldn't testiment to how accurate that actually is..

Do you mean 2 out of 3, type 2 that use insulin quit after a while?

 

[lucylocket61]

Do you mean 2 out of 3, type 2 that use insulin quit after a while?

I have been told that 30% of type 2 diabetics eventually use insulin as a treatment. Permenantly.

 

[Jaylee]

Do you mean 2 out of 3, type 2 that use insulin quit after a while?

What I read was what @lucylocket61 kinda said, only the actual figure looked like "30%?"
I saw no breakdown of statistics. Other than the usual blurb that 90% of all Ds are T2.
& the usual nonsense sensationalising the condition. (Like they do..)

 

[millenium]

I have been told that 30% of type 2 diabetics eventually use insulin as a treatment. Permenantly.

I think this is good news. Reason is because it is hard for one to have the discipline to limit carb intake (balance with physical activity) to a level for healthy blood glucose range. This is to say most diabetic type 2 patients do not control their blood glucose level well. In the end only 30% eventually went on to use exogenous insulin treatment, it says a lot on how resistant our body is to the repeated and prolonged blood glucose abuse.

If one is to use proper low carb diet and exercise routine to intervene, the chances of a full and long term remission is very high.

 

[lucylocket61]

I think this is good news. Reason is because it is hard for one to have the discipline to limit carb intake (balance with physical activity) to a level for healthy blood glucose range. This is to say most diabetic type 2 patients do not control their blood glucose level well. In the end only 30% eventually went on to use exogenous insulin treatment, it says a lot on how resistant our body is to the repeated and prolonged blood glucose abuse.

If one is to use proper low carb diet and exercise routine to intervene, the chances of a full and long term remission is very high.

Unfortunately you misunderstood. I mean within 10 years. Almost all the type 2 diabetics I know are on insulin. As someone who has ME, I don't exercise. It's all about the carbs.

I don't consider the carb control issues some may have, to be a lack of self discipline. I consider it to be a lack of information and support from the medical people. I have had to go it alone, in the face of hostility from my DN, despite the evidence of my figures, for nearly 10 years now. It is scandalous.

 

[Mr_Pot]

I have been told that 30% of type 2 diabetics eventually use insulin as a treatment. Permenantly.

That may well be true historically but then that was the about the only treatment, there are now many types of medication that can be tried before Insulin and so it may never be needed. I am hopeful that diet may be enough for me in the long term but at 74 the long term is not so far away as for some.

 

[bulkbiker]

I have been told that 30% of type 2 diabetics eventually use insulin as a treatment. Permenantly.

If they follow the mainstream guidance I find it odd that it is so low..

 

[millenium]

Unfortunately you misunderstood. I mean within 10 years. Almost all the type 2 diabetics I know are on insulin. As someone who has ME, I don't exercise. It's all about the carbs.

I don't consider the carb control issues some may have, to be a lack of self discipline. I consider it to be a lack of information and support from the medical people. I have had to go it alone, in the face of hostility from my DN, despite the evidence of my figures, for nearly 10 years now. It is scandalous.

Most diabetes T2 probably mess up their BG, so it is no surprise.

 

[KK123]

Most diabetes T2 probably mess up their BG, so it is no surprise.

You don't have diabetes yourself do you? Personally I think you should be careful of such statements, it's not always about an individual 'messing things up', or that somehow people must be doing something wrong if they don't get into remission, etc. It's interesting to me how people feel they can speak about groups of people who share a health condition they themselves don't have any experience of, such as diabetes in a way they would never apply to a group of people with cancer for example.

 

[lucylocket61]

Most diabetes T2 probably mess up their BG, so it is no surprise.

Yeah, let's continue to blame the diabetics........(sarcasm)

 

[Dollylolly]

I’m surprised that your uncle is being or on insulin and empagiflozin as that’s a rather strong load.

if already on this is he testing to see what his BG are daily.

be aware the flozin will increase urine production and cause UTIs and Yeast infections unless he’s reduced his carb load.

my mother was put on insulin snd her numbers went crazy all the time and what did the docs do increase her insulin. She was on huge amounts at the end and it wasn’t working. It killed her in the end through a diabetic coma and it induced a massive stroke at 70

I was dx at the same age as her at 50, 2017 my numbers went to 106 and they wanted me on insulin tried sending me to the hospital specialists I refused as I felt that insulin would rot me from the inside out.

I went back to low carbing to be told I’ll be on insulin in the future regardless thanks Nurse but I’ve not in the past 4 years and I’ve tried to stay under 100g of carbs a day. I haven’t fallen of the wagon but do have treats now and again.