Understanding insulin resistance and fats. New data.

Mr_Phillips 2 · Dec 25, 2020

Merry Christmas everyone.

The two charts below seem to indicate that we have been barking up the wrong tree with our many theories about fats and insulin resistance. You will note that although the timeline is not perfect, the charts reviewed in unison highlights a couple of important points. Please also bear in mind that my treatment with cannabis oil started in Sep2016 and it’s effects on my HbA1c from that date.

The fat around my waist on Dec2016 of 88cm was still there but yet my HbA1c levels fell.
This fat subsequently fell by the next reading on Nov2017 by a huge 7cm. I suspect that this was as a consequence of stopping my prescription medicine of glicizide in June2016, as I cannot think of any other explanations for this.

So.....what caused my diabetes to rear its ugly head. There is no family history of any diabetes in my family and I have never been overweight. So if I have to hazard a guess as to what triggered my type 2, I will tentatively suggest that it has to do with inflammation of the cell receptors. This seems an overly simplified explanation and I hope that the many experienced and knowledgable people can throw more light on this subject.

Weights and measurements

Date. Weight. Waist. BMI. Height.

Nov 17: 66kg. 81cm. 24.5. 164cm

Dec 16: 66kg. 88cm. 24.5

Feb 13: 66kg. 85cm. 23.10

HbA1C READINGS.

Nov17: 42 or. 6.0%

Jun17: 43 or. 6.1%

Nov16: 45 or. 6.3%

Feb16: 51 or 6.8%

May15: 47 or 6.4%

Jun14: 52 or 6.9%

Feb14: 86 or 10%

May13: 50 or 6.7%

Feb13: 58 or 7.5%

By the way, my first post was over three years ago and it was about my treatment and can be found under Mr. Phillips. This is my second post and this is specifically about data analysis.

Resurgam · Dec 25, 2020

For over 40 years whenever I went to the doctor feeling ill the response came back 'its because you are fat' - or overweight - even when I had a 24 inch waist.
It is something like a Pavlovian reflex - it has been translated into 'it would probably help if you lost some weight' these days - but the reason your Hba1c went down was most likely due to alterations in your carbohydrate regime and response and SATD with fat.

Lamont D · Dec 25, 2020

One of the reasons that insulin resistance has a bearing on your weight and health is because the unused insulin produced has to go somewhere, it is converted to fat and most likely around your organs. This can also lead to higher levels of insulin circulating in your bloodstream. This can also give you a condition called hyperinsulinaemia. It is known that too much high insulin is one of the causes of T2 diabetes.
Another known cause which has an effect is inflammation of the blood cells. Inflammation has an adverse effect on your health.

I have a theory obviously not proven that carb intolerance to many that are susceptible to inflammation or a metabolic condition, has been the cause of the rise of type two diabetes in this country.
The sale of concoctions that are now derived from wheat, sugar and manufacture of junk food, along with insulin resistance is a major indicator of why.

Brunneria · Dec 25, 2020

@Mr_Phillips 2

insulin resistance and developing T2 are a great deal more complex than is usually assumed.
Age, age related metabolic and hormonal changes, age related physical deterioration, the proportion of muscle to non muscle, activity/fitness levels, weather/climate, diet and carb and fructose and alcohol intake all play their parts. Along with many other factors. Visceral fat in the pancreas and liver are major players, but they won’t necessarily show up on a tape measure.

i would suggest that it isn’t about barking up the wrong tree, rather that we actually need to be barking up several trees at once, while doing so at a different volume for each tree.

Daibell · Dec 25, 2020

Form what you say there is a possibility your are a T1/LADA being slim? If so this would be due to a failing beta cells and not insulin resistance. The weight loss when you stopped Gliclazide could have been due partly to having too many carbs when on the Glic? We would need more information to be able to make more guesses

Mbaker · Dec 25, 2020

I think Ben Bikman has a good handle on insulin resistance. Looking at your scenario there are some figures such as weight and bmi, which by themselves are not the full picture. For example have you maintained by caloric restriction, which foods and in what quantities are being consumed, how has body composition changed, what are insulin, stress levels, hs-crp, trigs.

Gliclazide forces the pancreas to overwork, which could have a burn out affect.

You might be an outlier, who does not fit a type. I would get cross referential tests.

Mr_Phillips 2 · Dec 26, 2020

Resurgam said:
For over 40 years whenever I went to the doctor feeling ill the response came back 'its because you are fat' - or overweight - even when I had a 24 inch waist.
It is something like a Pavlovian reflex - it has been translated into 'it would probably help if you lost some weight' these days - but the reason your Hba1c went down was most likely due to alterations in your carbohydrate regime and response and SATD with fat.

Thanks for your response and it is quite possible that what you suggested could have been the reason. I do not know because I do not count calories or know how to.

Mr_Phillips 2 · Dec 26, 2020

Lamont D said:
One of the reasons that insulin resistance has a bearing on your weight and health is because the unused insulin produced has to go somewhere, it is converted to fat and most likely around your organs. This can also lead to higher levels of insulin circulating in your bloodstream. This can also give you a condition called hyperinsulinaemia. It is known that too much high insulin is one of the causes of T2 diabetes.
Another known cause which has an effect is inflammation of the blood cells. Inflammation has an adverse effect on your health.

I have a theory obviously not proven that carb intolerance to many that are susceptible to inflammation or a metabolic condition, has been the cause of the rise of type two diabetes in this country.
The sale of concoctions that are now derived from wheat, sugar and manufacture of junk food, along with insulin resistance is a major indicator of why.

Oh, I have no doubts it is a carb intolerance but what caused this condition? I have always suspected that I have some sort of inflammation issue and if I am not mistaken I remember seeing some elevated readings In my records in the past. I will need to have another look again. Inflammation is caused by so many things including sleep and stress.

bulkbiker · Dec 26, 2020

Mr_Phillips 2 said:
Inflammation is caused by so many things including sleep and stress.

And diet.. don't forget that as it's probably the most important.
Years of dietary abuse (excess carbs) could be the answer to your conundrum.

Mr_Phillips 2 · Dec 26, 2020

Brunneria said:
@Mr_Phillips 2

insulin resistance and developing T2 are a great deal more complex than is usually assumed.
Age, age related metabolic and hormonal changes, age related physical deterioration, the proportion of muscle to non muscle, activity/fitness levels, weather/climate, diet and carb and fructose and alcohol intake all play their parts. Along with many other factors. Visceral fat in the pancreas and liver are major players, but they won’t necessarily show up on a tape measure.

i would suggest that it isn’t about barking up the wrong tree, rather that we actually need to be barking up several trees at once, while doing so at a different volume for each tree.

Yes, very possible that we need to bark up several trees but that is precisely where my problem is. My mindset is such that I hate to over complicate matters as we all know how easy it is to do so. I myself was barking up the sedentary lifestyle tree, as I retired about 15 years ago. So many trees makes it so confusing.

Mr_Phillips 2 · Dec 26, 2020

Daibell said:
Form what you say there is a possibility your are a T1/LADA being slim? If so this would be due to a failing beta cells and not insulin resistance. The weight loss when you stopped Gliclazide could have been due partly to having too many carbs when on the Glic? We would need more information to be able to make more guesses

It cannot possibly be failing beta cells as I have had normal hba1c numbers since. I have never dieted in my life.

Mr_Phillips 2 · Dec 26, 2020

Mbaker said:
I think Ben Bikman has a good handle on insulin resistance. Looking at your scenario there are some figures such as weight and bmi, which by themselves are not the full picture. For example have you maintained by caloric restriction, which foods and in what quantities are being consumed, how has body composition changed, what are insulin, stress levels, hs-crp, trigs.

Gliclazide forces the pancreas to overwork, which could have a burn out affect.

You might be an outlier, who does not fit a type. I would get cross referential tests.

Please accept my apologies for not having introduced myself. My excuse is that I am a lazy communicator. Let me formally introduce myself. Although my user name is Mr Phillips2, as some people seem to insist on calling me, my actual name is Philip or Phil.
I am sorry, but I can’t give you numbers as to what I consume. I normally eat home cooked food for about six days of the week and the last day is usually takeaways of Indian or Chinese. Home cook is usually a plate of boiled white rice and eaten with a dish of meat and a dish of vegetables. It may vary on occasions With noodles but generally it is the same.
As soon as I realised that stress is a major contributor, I did spend more time going for strolls in the park with my dog. Body composition appears to be the same. If there are any other data you require please do not hesitate.

Mr_Phillips 2 · Dec 26, 2020

bulkbiker said:
And diet.. don't forget that as it's probably the most important.
Years of dietary abuse (excess carbs) could be the answer to your conundrum.

Hello bulkbiker, I remember clearly a comment you made about a recent article about a nearly half million study about fats and BMI and your comment regarding Pharma sponsor. That was the spur for me to post here. Thank you. I don’t understand what you mean by the answer to my conundrum. Can you please explain.

Diane_56 · Dec 26, 2020

Dose gildside make you put weight on

bulkbiker · Dec 26, 2020

Mr_Phillips 2 said:
Hello bulkbiker, I remember clearly a comment you made about a recent article about a nearly half million study about fats and BMI and your comment regarding Pharma sponsor. That was the spur for me to post here. Thank you. I don’t understand what you mean by the answer to my conundrum. Can you please explain.

Maybe I misunderstood your initial question.. when you are talking about fats do you mean dietary fat or body fat?

Lamont D · Dec 26, 2020

Hi again @Mr_Phillips 2

My condition is fairly rare and one of the problems I had to get my head straight was, why me? Why have I got this condition and what caused it?

I searched high and low on the internet and asked my specialist, and nobody knows why. They can see what has happened to my body by doing all sorts of tests, but the real underlying cause is not known.
I could tell you it's the carbs, but why some carbs and not others? Is it the structure of some foodstuffs like starch? But why do I have an intolerance to dairy and grains and rice. Why won't my brain let me e eat boiled greens? And why can't I eat potatoes?
They rocket my blood glucose levels! Why is it my pancreas goes from not having enough insulin when I eat and too much about an hour and keeps on producing while my digestive system works.
I am carb intolerant. The tests prove this, but how?
Obviously the questions are rhetorical, but I had to stop thinking about why it has happened, to what can I do to get my life back and stop the deterioration of my body, stop the hypos and subsequent symptoms. If my specialist hadn't noticed my hypos and my food diary to give him a clue to what was happening and get the necessary tests done to establish diagnosis. I know I wouldn't be here.
My advice is yeah, research, see if you can explore the reasons but put more thought and action into discovering what is good and what is not good.
In sport, you have to be proactive rather than reactive.

This is why this forum has been so helpful, the suggestions used do work and of course you can discover a lot of valid information that will certainly help you.

Keep safe.
Keep asking, knowledge is one of the best tools for your treatment, but always keep an open mind about your diet, the thing you love and enjoy may be slowly making you have problems in the future.

Mr_Phillips 2 · Dec 26, 2020

Diane_56 said:
Dose gildside make you put weight on

I understand it aids insulin production which = body fats

Mr_Phillips 2 · Dec 26, 2020

bulkbiker said:
Maybe I misunderstood your initial question.. when you are talking about fats do you mean dietary fat or body fat?

Body fat

Mr_Phillips 2 · Dec 26, 2020

Lamont D said:
Hi again @Mr_Phillips 2

My condition is fairly rare and one of the problems I had to get my head straight was, why me? Why have I got this condition and what caused it?

I searched high and low on the internet and asked my specialist, and nobody knows why. They can see what has happened to my body by doing all sorts of tests, but the real underlying cause is not known.
I could tell you it's the carbs, but why some carbs and not others? Is it the structure of some foodstuffs like starch? But why do I have an intolerance to dairy and grains and rice. Why won't my brain let me e eat boiled greens? And why can't I eat potatoes?
They rocket my blood glucose levels! Why is it my pancreas goes from not having enough insulin when I eat and too much about an hour and keeps on producing while my digestive system works.
I am carb intolerant. The tests prove this, but how?
Obviously the questions are rhetorical, but I had to stop thinking about why it has happened, to what can I do to get my life back and stop the deterioration of my body, stop the hypos and subsequent symptoms. If my specialist hadn't noticed my hypos and my food diary to give him a clue to what was happening and get the necessary tests done to establish diagnosis. I know I wouldn't be here.
My advice is yeah, research, see if you can explore the reasons but put more thought and action into discovering what is good and what is not good.
In sport, you have to be proactive rather than reactive.

This is why this forum has been so helpful, the suggestions used do work and of course you can discover a lot of valid information that will certainly help you.

Keep safe.
Keep asking, knowledge is one of the best tools for your treatment, but always keep an open mind about your diet, the thing you love and enjoy may be slowly making you have problems in the future.

I am sorry but I do not know enough to suggest anything. I have always thought that the best way to prove that the cause is inflammation is to maybe research into what prescription drugs control inflammation and whether it can be taken continuously to control said inflammation and than check ones HbA1c after three months to see if it has improved. The question is is there such a drug that is safe for me to try?

Mr_Phillips 2 · Dec 26, 2020

As requested.

Weights and measurements

Date. Weight. Waist. BMI. Height.

Jan 20: 65kg. 82cm. 24. 164cm

Nov 17: 66kg. 81cm. 24.5. 164cm

Dec 16: 66kg. 88cm. 24.5

Feb 13: 66kg. 85cm. 23.10

HbA1C READINGS.

Jan20: 39 or 5.7%

Oct19: 36 or 5.4%

May19: 41 or 5.9%

Dec18: 38 or 5.6%

Oct18: 39 or. 5.7%

Mar18: 40 or. 5.8%

Nov17: 42 or. 6.0%

Jun17: 43 or. 6.1%

Nov16: 45 or. 6.3%

Sep16: Started cannabis oil dose

Jun16: Stopped taking doctors prescription of 80mg Glicizide tablets for diabetes.

Feb16: 51 or 6.8%

Dec15: Started walking dog

May15: 47 or 6.4%

Jun14: 52 or 6.9%

Feb14: 86 or 10%

May13: 50 or 6.7%

Feb13: 58 or 7.5%

Understanding insulin resistance and fats. New data.

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