https://academic.oup.com/jcem/artic...ulin-Resistance-as-a-Predictor-of-Age-Related
This paper pretty much states the theory but applies to to healthy non obese individuals - Looking at the various lipid profiles
I fall into the healthiest group except for blood pressure and weight.
The interesting thing about this is that it basically says those with the best insulin responses had NO diseases of anything in the study. The biggest differentiators were insulin and (trigs) exactly as I would expect. Health was not correlated to weight ( though I would question if the weight bands were big enough to notice in this study)
The Conclusion
This study was initiated to evaluate the hypothesis that insulin resistance would predict the development, over time, of clinical syndrome that might be best subsumed under the heading of age-related diseases (HT, CHD, stroke, cancer, and type 2 diabetes). Although the results provide substantial support for this point of view, perhaps the most striking finding was that none of these events were seen in the third of the population that was most insulin-sensitive. Given the fact that the period of observation ranged from 4–11 yr, with an average follow-up of 6.3 yr, the fact that not one clinical event took place in the insulin-sensitive tertile seems to be truly remarkable. If the ability of insulin sensitivity to decrease risk of developing age-related diseases can be confirmed in subsequent studies, the public health implications are enormous.
So then I look at this table showing a bunch of people on LCHF , number of days on diet plotted against fasting insulin
Fasting insulin levels appear to be correlated to time on an LCHF diet in T2 diabetics who can bring their health markers including glucose, Hba1C and levels of circulating insulin down to normal levels through diet
I would then question is it Insulin sensitivity per se - or is it simply the level of circulating insulin at all.
Overall it looks to me like these are not " age related " diseases at all they are metabolic diseases brought on by metabolic derangement caused by eating food that drive insulin responses and insulin resistance where the human body can only deal with it for so long depending on the level of abuse it takes in the diet.
The good news for diabetics would be that the way you know your fasting insulin is going down is that you don't need it / or as much of it if you don't eat carbs/ processed foods and the chances are that the longer you keep up an LCHF lifestyle the better off you will be.
The same may well apply to either fasting or VLC I don't have any data for that as its not something I've tried.