· The Twin Cycle Hypothesis suggested that excess fat gradually accumulated in liver then pancreas eventually causing loss of glucose control.
All studies since have shown that this explains both the cause of type 2 diabetes and its remission https://wchh.onlinelibrary.wiley.com/doi/10.1002/pdi.2297
The Twin Cycle is just a theory, and it has not been proven. The work done by Newcastle a/c has demonstrated that there is a possible association between ectopic hepatic fat and glucose intolerance in T2D, but it does NOT prove that the fat
causes T2D, and does not consider that the effect may in fact be due to Insulin resistance Since the diet used by Taylor et al removed hepatic fat, it also removes mitochondrial fat, and this would possibly indicate a different form of IR in the muscle tissue. As I have said in another thread here, it may be a signalling issue and not a physical change to the beta cells. The Newcastle Study has not separated any of these potential confounders.
The Diet has a limited success rate. If it had had 100% success, and the effect was more permanent, then maybe the Twin Cycle may hold some water, but at the moment what you have written here is incomplete and incorrect. So far there has been no corroborating evidence providing any measure of proof. Prof Taylor is a single source for this theory. It is his viewpoint, that's all. Another piece in the jigsaw.