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I'm trying to read something and am out of my depth. Can anyone comment on this and make it clearer?
I guess the main thing I'm trying to understand is this: Can eating very low carb cause inflammation by increasing fatty acid oxidation? Or does it reduce inflammation (which is what I assumed)?
I've read somewhere that fatty acid oxidation, which happens in the fasted state (and I assume when you restrict carbohydrates by following a keto or carnivore diet), improves your health and reduces inflammation. I can't find where I read that though and I might just be making that up.
But now I am looking at this article (linked below) and it seems to say that increased fatty acid oxidation is associated with health problems like T2. ... I'm confused. Can anyone help?
It says: "Energy metabolism in the aerobic heart differs from that in the insulin-resistant heart (fig. 1). In the latter, fatty acids are favored as an energy source over glucose, which is thus associated with increased fatty acid oxidation, and an overall decrease in glycolysis and glucose oxidation. (Wouldn't this be a coping mechanism? And I also don't get how you can mobilize fatty acids if you are feeding your body glucose via carbs. Again though, I not sure I understand any of this properly..)
"As muscle fatty acid uptake and oxidation is increased in insulin-resistant and diabetic individuals, increased fatty acid metabolism can thus directly impair glucose metabolism in muscle. In addition, accumulation of fatty acid metabolites in muscle can impair insulin signaling," (Is this also the same as the physiological insulin resistance people experience when in ketosis?)
https://www.karger.com/Article/Fulltext/448357
"In well-fed animals the liver converts excess carbohydrates to fatty acids, whereas in fasting animals fatty acid oxidation is the predominant activity, along with the formation of ketones.
https://www.britannica.com/science/lipid/Mobilization-of-fatty-acids
I guess the main thing I'm trying to understand is this: Can eating very low carb cause inflammation by increasing fatty acid oxidation? Or does it reduce inflammation (which is what I assumed)?
I've read somewhere that fatty acid oxidation, which happens in the fasted state (and I assume when you restrict carbohydrates by following a keto or carnivore diet), improves your health and reduces inflammation. I can't find where I read that though and I might just be making that up.
But now I am looking at this article (linked below) and it seems to say that increased fatty acid oxidation is associated with health problems like T2. ... I'm confused. Can anyone help?
It says: "Energy metabolism in the aerobic heart differs from that in the insulin-resistant heart (fig. 1). In the latter, fatty acids are favored as an energy source over glucose, which is thus associated with increased fatty acid oxidation, and an overall decrease in glycolysis and glucose oxidation. (Wouldn't this be a coping mechanism? And I also don't get how you can mobilize fatty acids if you are feeding your body glucose via carbs. Again though, I not sure I understand any of this properly..)
"As muscle fatty acid uptake and oxidation is increased in insulin-resistant and diabetic individuals, increased fatty acid metabolism can thus directly impair glucose metabolism in muscle. In addition, accumulation of fatty acid metabolites in muscle can impair insulin signaling," (Is this also the same as the physiological insulin resistance people experience when in ketosis?)
https://www.karger.com/Article/Fulltext/448357
"In well-fed animals the liver converts excess carbohydrates to fatty acids, whereas in fasting animals fatty acid oxidation is the predominant activity, along with the formation of ketones.
https://www.britannica.com/science/lipid/Mobilization-of-fatty-acids