I would discard any studies on mice, even if they seem to support a theory. (Also any study on humans using liquid standardised keto meals, and any keto ‘diet’ rich in veg oils)
poor mice. They get trotted out as examples of why all sorts of things are bad for humans, yet the diets and conditions used on the mice are appallingly wrong for any comparison with any human.
for a start, they are fed standardised ‘lab mouse chow’ containing highly processed ingredients and vegetable oils, added sugars, and so on. Even the ‘keto’ versions bear no relation to the actual food, made with real un-messed-about-with ingredients, that humans (usually) eat when they choose keto. Vegetable oils usually provide the fat content in lab mouse ‘chow’, with highly processed coconut oil providing all the sat fat. I don’t eat that way. Do you?
the mice are also highly bred laboratory strains selectively chosen for hereditary weight gain, and/or insulin resistance, and/or other genetic tendencies. Or whatever traits the researchers are looking for.
if I am going to be compared to a mouse, it would need to be one with a family history of gluten intolerance, arthritis, and gut problems, plus a generations long history of v late onset T2 (mice are culled at the end of every experiment so researchers never see the old ages of their charges), and that mouse should have a lifelong carb intolerance AND a lifelong history of responding extremely well to very low carb eating. They should have great cholesterol ratios (do mice even have comparable cholesterol ratios?), a zero CAC score, and an insulin resistance level that FALLS on keto, not rises. Because that would reflect me and my body.
once we’ve found about 50 mice like that, we can wait til they hit middle age, and then start the experiment. But we will need to feed them proper food both before and during the experiment. I’m not accepting a comparison unless they are eating human grade food, prepped in a kitchen, with no processed long shelf life ingredients.
oh, and I will need plenty of room for them to move around and exercise to their comfort level, too.
and a spacious comfortable retirement home (my spare bedroom would do, I think) for their old ages, and continued healthy diet.
however, even that experiment would convince me of nothing, unless someone provides me with research demonstrating that mice can
naturally eat keto or low carb in their
natural habitats. Because humans can. Without that as a starter for 10 on the research, everything would be an utter waste of research money and poor mouse lives.
https://www.google.co.uk/amp/s/www....n/inside-a-lab-mouses-high-fat-diet-34465/amp
there is an interesting reference in the link above which shows why comparing human and mouse reactions to high fat diets is misleading due to their very different physical reactions (incl weight gain).
ed. For clarity.