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New diabetic drug

Discussion in 'Type 2 Diabetes' started by Superchip, Jan 16, 2013.

  1. Superchip

    Superchip · Well-Known Member

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    Just received this from the BNF,

    Dapagliflozin
    Dapagliflozin, a new first-in-class antidiabetic drug, has been added to BNF section 6.1.2.3 for the treatment of type 2 diabetes. It reversibly inhibits sodium-glucose co-transporter 2 (SGLT2) in the renal proximal convoluted tubule to reduce glucose reabsorption and increase urinary glucose excretion. Dapagliflozin is licensed for use as monotherapy (if metformin is not tolerated), or in combination with insulin or other antidiabetic drugs (if existing treatment fails to achieve adequate glycaemic control), however, it is not recommended for use in combination with pioglitazone. For further information see Dapagliflozin.

    Any thoughts ? any peeps with a bit of training out there who can interpret this ?

    Superchip
     
  2. anna29

    anna29 Type 2 · Well-Known Member
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    After saying it a few times and looking at it spelled.

    It sounds and looks more like an antibiotic to me ... :eh:

    Anna.
     
  3. Osidge

    Osidge Type 2 · Well-Known Member
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    This drug works in the kidneys and causes the body to expel excess glucose and its associated calories in the urine. As a consequence it can reduce BS and also assist in weight loss. This drug was not approved in the USA by the FDA, who have asked for more information on risks. There is a later drug in this class, canagliflozin, which has been approved by the FDA, but has not, as yet, been approved by the EU, although the application has been made.

    Regards

    Doug
     
  4. Superchip

    Superchip · Well-Known Member

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    Thanks Doug, but it appears to be licenced according to the BNF ?
    or am I missing the obvious ?

    Quote from my previous post on the BNF site ' Dapagliflozin is licensed for use as monotherapy (if metformin is not tolerated), or in combination with insulin or other antidiabetic drugs (if existing treatment fails to achieve adequate glycaemic control'

    I am probably being a bit thick here, I ignore what the septics are doing with their drugs, there I go again, sorry !

    Thanks mate

    Superchip
     
  5. Osidge

    Osidge Type 2 · Well-Known Member
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    Dapagliflozin is licensed for EU use but the later drug, canagliflozin is not, as yet, licensed for EU use. In the USA it's the other way round as the FDA want more information on the risks of dapagliflozin but were happy with canagliflozin (by a narrow vote!).

    Doug
     
  6. the east man

    the east man · Well-Known Member

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    From what I read on the home page of this site, it is being used in Scotland. Dont know if they are trailing it, or just trying to be progressive. :?
     
  7. londoner

    londoner · Member

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    Has anyone tried the drug dapagliflozin? If so, how did you get on? Is it too new for any feedback?
     
  8. Osidge

    Osidge Type 2 · Well-Known Member
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    Hi all.

    I have just begun dapagliflozin this week. I suggested it to my GPSID and she said that she was going to mention it to me anyway. Too early to tell what it will achieve but no apparent side effects so far. I continue to take one 500mg tablet if Metformin a day but have now discontinued injecting Exenatide.

    Regards

    Doug


    Sent from the Diabetes Forum App
     
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  9. ickihun

    ickihun Type 2 · Master

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    Just an update. I tried the 100mg canagliflozin and resulted in scatica like symptoms and horrific thrush.
     
  10. Osidge

    Osidge Type 2 · Well-Known Member
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    Sorry for my late update. I had UTIs and balanitis and my endo advised me to stop using dapa.
     
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  11. chalup

    chalup Type 2 · Well-Known Member

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    I have been on forxiga for 2 months with no problems whatsoever. Also taking 1000mg metformin and low carb. Blood sugar has gone from the 20s to between 5 and 6.5.
     
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  12. greybags

    greybags Type 2 · Well-Known Member

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    How long before you started to see any improvement. I'm in the high teens, take 1000mg SR Metformin, and been on Forxiga for a week. Not seen any improvements yet, so just wondering what sort of time frame I should be expecting
     
  13. ickihun

    ickihun Type 2 · Master

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    It took a few months before I felt the nasty side effects.
    If you experience any leg or foot pain stop this tablet immediately.
    I will tag @liam1955 for his experiences.
     
  14. chalup

    chalup Type 2 · Well-Known Member

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    Hi

    It took a couple of weeks to come down but I also started a strict low carb diet at the same time. The low carb will also help with not being so likely to get thrush or UTI's as there will be less glucose in the urine. Last night I was at a BBQ and the burgers etc were not under my control. I did not eat any bun but the meat was full of fillers. Forxiga kept my BS well under 7 although I did have to pee more for a few hours. Best way to see the change is to write down all your numbers. There will be random higher and lower numbers, I think everyone gets those to some extent but you should see a general trend down. Fasting in the morning will be the last to start coming down and the forxiga will help if you have dawn phenomenon by getting it down a bit faster.
    Hope this helps
     
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