Cholesterol and Statins

[bulkbiker]

There are always a lot of threads about Statins and Cholesterol and we all post our various favourite bits of current presentations about them but I thought it might be handy to have them all in one thread. I meant to put this together soon after the get together in Birmingham (sorry @Debandez) but have been a bit distracted (thanks to twitter) since then so thought it was about time I pulled my finger out and put something down. I'll try and take the best bits of what I have posted previously and nick some bits from others... please anyone feel free to add what you find so we can have a one stop shop for the curious.

Full disclosure... I can't think of a single reason why I would take a statin.. ever

LDL Does Not Cause Cardiovascular Disease
https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391?scroll=top&needAccess=true

full study here
https://www.dropbox.com/s/pybuhn9wph2smgy/20180910 KENDRICK etc. LDL-C Does Not Cause Cardiovascular Disease - a comprehensive review.pdf?dl=0

Need a link to the great Dr Malcolm Kendrick... no statin page would be complete without the sceptic in chief...

https://drmalcolmkendrick.org/about/

Great piece explaining how statins work and the nasty things they may be doing to you by Nick Mailer

Why your LDL may go up on a low carb/ketogenic regime

Dave Feldman and of course a link to his site

http://cholesterolcode.com

Statins stimulate atherosclerosis?

http://explore.tandfonline.com/content/med/statins-stimulate-atherosclerosis-and-heart-failure

Flaws in early statin trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513492/
" Curiously, statin trials conducted after 2005 have failed to demonstrate a consistent mortality benefit"

Statin induced diabetes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156828/

Statin induced peripheral neuropathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103035/

Prof Sherif Sultan doesn't like them much either and he is/was President of International Society for Vascular Surgery

Nor does David Diamond

Also a huge amount of info from Ivor Cummins

http://www.thefatemperor.com

Hopefully that will be a start...

 

[Hotpepper20000]

There are always a lot of threads about Statins and Cholesterol and we all post our various favourite bits of current presentations about them but I thought it might be handy to have them all in one thread. I meant to put this together soon after the get together in Birmingham (sorry @Debandez) but have been a bit distracted (thanks to twitter) since then so thought it was about time I pulled my finger out and put something down. I'll try and take the best bits of what I have posted previously and nick some bits from others... please anyone feel free to add what you find so we can have a one stop shop for the curious.

Full disclosure... I can't think of a single reason why I would take a statin.. ever

LDL Does Not Cause Cardiovascular Disease
https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391?scroll=top&needAccess=true

full study here
https://www.dropbox.com/s/pybuhn9wph2smgy/20180910 KENDRICK etc. LDL-C Does Not Cause Cardiovascular Disease - a comprehensive review.pdf?dl=0

Need a link to the great Dr Malcolm Kendrick... no statin page would be complete without the sceptic in chief...

https://drmalcolmkendrick.org/about/

Great piece explaining how statins work and the nasty things they may be doing to you by Nick Mailer

Why your LDL may go up on a low carb/ketogenic regime

Dave Feldman and of course a link to his site

http://cholesterolcode.com

Statins stimulate atherosclerosis?

http://explore.tandfonline.com/content/med/statins-stimulate-atherosclerosis-and-heart-failure

Flaws in early statin trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513492/
" Curiously, statin trials conducted after 2005 have failed to demonstrate a consistent mortality benefit"

Statin induced diabetes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156828/

Statin induced peripheral neuropathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103035/

Prof Sherif Sultan doesn't like them much either and he is/was President of International Society for Vascular Surgery

Nor does David Diamond

Also a huge amount of info from Ivor Cummins

http://www.thefatemperor.com

Hopefully that will be a start...

Thank you for putting all this information in one thread!!!!

 

[hankjam]

Good piece of work and time well spent.
Cheers @bulkbiker

 

[KK123]

Great post and very helpful, thank you.

 

[Bluetit1802]

Thank you @bulkbiker what a wonderful idea. It could be even better if it were made a sticky somewhere.

 

[bulkbiker]

Thank you @bulkbiker what a wonderful idea. It could be even better if it were made a sticky somewhere.

Not my idea.... it was that @Debandez wot dun it!

 

[Debandez]

Not my idea.... it was that @Debandez wot dun it!

I LOVE it!!! Your comment did make me smile....a lot @bulkbiker.

 

[Debandez]

There are always a lot of threads about Statins and Cholesterol and we all post our various favourite bits of current presentations about them but I thought it might be handy to have them all in one thread. I meant to put this together soon after the get together in Birmingham (sorry @Debandez) but have been a bit distracted (thanks to twitter) since then so thought it was about time I pulled my finger out and put something down. I'll try and take the best bits of what I have posted previously and nick some bits from others... please anyone feel free to add what you find so we can have a one stop shop for the curious.

Full disclosure... I can't think of a single reason why I would take a statin.. ever

LDL Does Not Cause Cardiovascular Disease
https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391?scroll=top&needAccess=true

full study here
https://www.dropbox.com/s/pybuhn9wph2smgy/20180910 KENDRICK etc. LDL-C Does Not Cause Cardiovascular Disease - a comprehensive review.pdf?dl=0

Need a link to the great Dr Malcolm Kendrick... no statin page would be complete without the sceptic in chief...

https://drmalcolmkendrick.org/about/

Great piece explaining how statins work and the nasty things they may be doing to you by Nick Mailer

Why your LDL may go up on a low carb/ketogenic regime

Dave Feldman and of course a link to his site

http://cholesterolcode.com

Statins stimulate atherosclerosis?

http://explore.tandfonline.com/content/med/statins-stimulate-atherosclerosis-and-heart-failure

Flaws in early statin trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513492/
" Curiously, statin trials conducted after 2005 have failed to demonstrate a consistent mortality benefit"

Statin induced diabetes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156828/

Statin induced peripheral neuropathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103035/

Prof Sherif Sultan doesn't like them much either and he is/was President of International Society for Vascular Surgery

Nor does David Diamond

Also a huge amount of info from Ivor Cummins

http://www.thefatemperor.com

Hopefully that will be a start...

This is amazing!!! Thanks @bulkbiker .....you are a star, always.

 

[Guzzler]

Totally should be a sticky.

 

[bulkbiker]

Feel I should add this one if only for this quote..

https://www.amjmed.com/article/S0002-9343(18)30404-2/fulltext?dgcid=raven_jbs_etoc_email

"Promoting foods that are low in cholesterol but typically high in refined carbohydrates is supposed to help prevent coronary heart disease. Paradoxically, there is now evidence that these dietary changes have contributed to the epidemic of diabetes that can actually lead to coronary heart disease. Furthermore, some statin users mistakenly believe they can eat whatever they want, leading to the phenomenon of statin gluttony. Consider also that the recent expansion of statin indications may result in millions of healthy individuals being treated because of a risk score even though they may be at extremely low risk of coronary heart disease."

 

[shelley262]

There are always a lot of threads about Statins and Cholesterol and we all post our various favourite bits of current presentations about them but I thought it might be handy to have them all in one thread. I meant to put this together soon after the get together in Birmingham (sorry @Debandez) but have been a bit distracted (thanks to twitter) since then so thought it was about time I pulled my finger out and put something down. I'll try and take the best bits of what I have posted previously and nick some bits from others... please anyone feel free to add what you find so we can have a one stop shop for the curious.

Full disclosure... I can't think of a single reason why I would take a statin.. ever

LDL Does Not Cause Cardiovascular Disease
https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391?scroll=top&needAccess=true

full study here
https://www.dropbox.com/s/pybuhn9wph2smgy/20180910 KENDRICK etc. LDL-C Does Not Cause Cardiovascular Disease - a comprehensive review.pdf?dl=0

Need a link to the great Dr Malcolm Kendrick... no statin page would be complete without the sceptic in chief...

https://drmalcolmkendrick.org/about/

Great piece explaining how statins work and the nasty things they may be doing to you by Nick Mailer

Why your LDL may go up on a low carb/ketogenic regime

Dave Feldman and of course a link to his site

http://cholesterolcode.com

Statins stimulate atherosclerosis?

http://explore.tandfonline.com/content/med/statins-stimulate-atherosclerosis-and-heart-failure

Flaws in early statin trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513492/
" Curiously, statin trials conducted after 2005 have failed to demonstrate a consistent mortality benefit"

Statin induced diabetes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156828/

Statin induced peripheral neuropathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103035/

Prof Sherif Sultan doesn't like them much either and he is/was President of International Society for Vascular Surgery

Nor does David Diamond

Also a huge amount of info from Ivor Cummins

http://www.thefatemperor.com

Hopefully that will be a start...

Well done on this one @bulkbiker what a brilliant resource for us all

 

[Indy51]

some statin users mistakenly believe they can eat whatever they want, leading to the phenomenon of statin gluttony.

Ah yes, the old 'magic pill', 'silver bullet' myth. Unfortunately a lot of Type 2's seem to labour under the same magical thinking - the GP will be able to fix things for me and I won't need to change a thing

 

[bulkbiker]

https://www.ncbi.nlm.nih.gov/pubmed/29733423?dopt=Abstract

Got heart failure? Low LDL is not good for you.

 

[NicoleC1971]

Ah yes, the old 'magic pill', 'silver bullet' myth. Unfortunately a lot of Type 2's seem to labour under the same magical thinking - the GP will be able to fix things for me and I won't need to change a thing

I was listening to an Aseem Malhotra anecdote in which a cardiology professor stood up at conference and said something like for those who hate exercise, like me, you can take a statin. If like a bike helmet or a seat belt a statin actually helped any but those with established heart disease (number needed to treat = 83 based on recent meta anlaysis of even the pharma biased big drug trials) though) then might be a rational choice.
Now where can I get that t shirt ' I cannot think of any reason to take a statin ..ever'. Probably too old to be wearing slogans tees I suppose...

 

[bulkbiker]

I was listening to an Aseem Malhotra anecdote in which a cardiology professor stood up at conference and said something like for those who hate exercise, like me, you can take a statin. If like a bike helmet or a seat belt a statin actually helped any but those with established heart disease (number needed to treat = 83 based on recent meta anlaysis of even the pharma biased big drug trials) though) then might be a rational choice.
Now where can I get that t shirt ' I cannot think of any reason to take a statin ..ever'. Probably too old to be wearing slogans tees I suppose...

Never too old for that one!.. in fact as we know for women the older you are the better you are with cholesterol higher...

 

[Guzzler]

I thought I'd share this one from Kendrick even though I disagree on the topic of PUFAs. It's an hour on Cholesterol, SatFats, CVD and stress among other things.

 

[Guzzler]

This one is not new (2015) but it has the basics and at twenty minutes it is great for anyone just starting on their research. Prof. Sikaris "Cholesterol - when to worry".

 

[bulkbiker]

Not sure if I have this one in already but always good to repeat it

https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391?scroll=top&needAccess=true

Oops just seen I have it already but hey read it twice!

 

[Resurgam]

I just realized that the last knitting magazine I bought was December 2016 - a periodical I have bought every month for decades, machine knitting is my profession, my interest and only source of income.
When I went to the exhibition held locally last weekend, I was surprised, and it slowly dawned on me that I'd not been getting them for some time. I thought that I was recovering - and things have definitely changed so I can remember better - but even though the collection of magazines is on show it never occurred to me that there were no new ones. I have now ordered back issues and got a subscription in place, but I am now wondering what else there is lost and forgotten.

 

[bulkbiker]

I'll add this one in too for people unsure about LDL.

https://blog.undoctored.com/what-bi...k9EBFbJpmkiXJy7HhSW3IrygzpdTlAYOcCo3QG-w7WuYw