Is the ketogenic diet more effective for weight loss than other diets?
In a meta-analysis of 13 studies lasting longer than a year, researchers found that the ketogenic diet was associated with less than a kilogram of additional weight loss over high-carbohydrate, low-fat strategies.This difference, although statistically significant, may not be clinically significant. Furthermore, a meta-analysis of 32 controlled feeding studies found that energy expenditure and fat loss were greater with low-fat diets compared with ketogenic diets.
Any diet that results in weight loss does so because it reduces calorie intake. The ketogenic diet, when used for weight loss, is no different.
The salient questions are whether it is sustainable and whether it promotes long-term health. No studies, to our knowledge, have evaluated ketogenic diets for cardiovascular events or mortality, although observational studies in the broader low-carbohydrate diet literature suggest increased all-cause mortality.