I have concluded that people with my genetics turn on and off insulin resistance./the 'thrifty gene'

[Indy51]

I'm wondering why insulin resistance fights weight loss too.
Someone on here once said insulin doesnt add weight. For some, I corrected as I assume insulin is preventing weight loss.
So if not insulin nor excessive food then what?
This OP wonders like me what causes insulin resistance to not be deminished or lost when many sufferers loss weight even.
I'm eating small amounts of food. No way enough to sustain my nearly 20stones. I still do not lose weight. I exercise, I still dont lose weight. I go low carb still no loss other than a rebounding few pounds. Loss then gain.
Why is my body in survival mode when im not starving nor walking 100s of miles a day?
OP is looking for answers from posters who look like they have the diabetes game beat.
As already pointed out..we are not medically trainer nor specialists in the field. OP would be better off quizzing his/her endocrinologist.
They know far more than I. Sorry. I cannot help with your enquiry either.
If we knew the answer we would be rich too.
I wish the OP the best of luck in finding a solution to supplement healthy food and exercise for insulin resistant sufferers.
Ps. Not all posters are not insulin resistant or at least not as severe as some. Fat will always be the whipping boy!
Ive had it all my life. Tell me something I dont know, being fat isnt healthy!
I feel your frustration too.
Your a proactive person but this gets us all fed up.
There is no solution other than an assisting diet, my friend. Kind regards in your plight.

In Dr Bernstein's latest webinar, he talked specifically about PCOS and how difficult it is for people to lose weight. @Galja posted the link elsewhere on the forum. He talked about people not losing weight and appearing to "live on air"

 

[Jaylee]

That is not a bad point to make.
Maybe my body has forgot to lose weight on a variant of dementia/Alzheimers?

Actually, what I was tactfully trying to convey was my T2 dad towards the end of his life was off the meds for his diabetes. (Metformin.)
True, I had managed to encourage a lower carb aproach In his diet. However. His vascular dementia (so I was told by the doctor.) was causing wierd fluctuations in his BG. (Including hypoglycaemia 3.4mmol an hour or so after breakfast.. (He was prescribed a meter. Unusually for a T2.)

A bit like the "ECU" on a car playing up with the engine managment regarding fuel delivery to the engine?
Hence why I urge the OP (with the best will in the world.) to get checked out for any issues for Altziemers while getting looked at for the RH??

 

[ickihun]

In Dr Bernstein's latest webinar, he talked specifically about PCOS and how difficult it is for people to lose weight. @Galja posted the link elsewhere on the forum. He talked about people not losing weight and appearing to "live on air"

Yes pcos does it too.
Underactive thyroid too, both of which I have as well as IR.
Hence no weight loss!
Happy days. :-(

 

[AndBreathe]

I'm wondering why insulin resistance fights weight loss too.
Someone on here once said insulin doesnt add weight. For some, I corrected as I assume insulin is preventing weight loss.
So if not insulin nor excessive food then what?
This OP wonders like me what causes insulin resistance to not be deminished or lost when many sufferers loss weight even.
I'm eating small amounts of food. No way enough to sustain my nearly 20stones. I still do not lose weight. I exercise, I still dont lose weight. I go low carb still no loss other than a rebounding few pounds. Loss then gain.
Why is my body in survival mode when im not starving nor walking 100s of miles a day?
OP is looking for answers from posters who look like they have the diabetes game beat.
As already pointed out..we are not medically trainer nor specialists in the field. OP would be better off quizzing his/her endocrinologist.
They know far more than I. Sorry. I cannot help with your enquiry either.
If we knew the answer we would be rich too.
I wish the OP the best of luck in finding a solution to supplement healthy food and exercise for insulin resistant sufferers.
Ps. Not all posters are not insulin resistant or at least not as severe as some. Fat will always be the whipping boy!
Ive had it all my life. Tell me something I dont know, being fat isnt healthy!
I feel your frustration too.
Your a proactive person but this gets us all fed up.
There is no solution other than an assisting diet, my friend. Kind regards in your plight.

Ickihun, Professor Taylor explains insulin resistance very well, and very simply in many of his presentations, using a bicycle analogy. Have a watch sometime.

 

[ladybird64]

Seeing as no moderator seems to have picked up on the attitude, and rudeness, in some of the OP's posts, I'll comment on it.

Neil, your remarks about your fellow posters are bordering on downright offensive. Everybody on this thread spends most of their time here helping others, answering questions and kindly offering advice - do you?

Immorality, self centred ..give me a break. Being a scientist does not elevate you to a higher position here so kindly show some respect please.

 

[ickihun]

Am I missing something?

 

[Lamont D]

@ickihun,

Even though, I have now lost a lot of weight.
A lot of my gradual weight gain was due to excessive insulin converting to visceral fat.
I know you have heard all the reasons for it and no matter what you do or eat, you still gain weight. The reason is not how much you eat, it is usually some food or drink that triggers the excess insulin, it could be anything, and if I have learned anything, it's that it could be anything including protein.
Unless you obsessively test and record everything you might or might not find out.
Also, having PCOS and your thyroid will not help with your other hormones.

A family member has the same issues, with general anxiety disorder on top, but she has one hyperthyroidism and one hypothyroidism to deal with, she has lost a little but rebounds quickly if she eats more than her body needs and creates more insulin, cortisol and her hormones are all over the place especially during that time of the month! (Hate discussing woman's things!) She has been eating very low carb and feels better but the weight goes nowhere!

Insulin resistance will not go away until you get really good control of your hormones, and that is so difficult to find out why you react to something that can't possibly put weight on but it does!
If I remember fasting didn't work for you or you feel awful after a while.
That's what got rid of my insulin resistance and started my weight loss and once I started it fell off quickly. I learned a lot from my fasting stay in hospital and how good I felt and how rejuvenated I was and the energy levels were something to behold.
Just by fasting for a few days.
I still fast intermittently, because of my working life.
You may have to rethink your lifestyle and see how you do experimenting with foods that you don't think would spike you.
I'm just thinking outside the box to try and help you.
I could be totally wrong though!

 

[LittleGreyCat]

Seeing as no moderator seems to have picked up on the attitude, and rudeness, in some of the OP's posts, I'll comment on it.

Neil, your remarks about your fellow posters are bordering on downright offensive. Everybody on this thread spends most of their time here helping others, answering questions and kindly offering advice - do you?

Immorality, self centred ..give me a break. Being a scientist does not elevate you to a higher position here so kindly show some respect please.

@yetta2mymom

I would also point out that the OP has shown no signs of any scientific approach or training. In fact some of the responses have been both unpleasant and unscientific.

I (and probably others) would, of course, welcome some details of Universities attended, qualifications achieved, papers published, posts held in scientific establishments and any other evidence to back up the claim of being a scientist.

 

[yetta2mymom]

I theorize that the hunter gene allows people to only store sugar when their blood sugar rises above some value (2). Consider the following. Evolutionary changes are often additions to existing processes. Women with the “hunter” gene have insulin resistance in pregnancy. Insulin is needed to process protein. Look at my glucose tolerance test (1). I am lead to the following weird conclusion. With the “hunter” gene people are normally in a state of insulin resistance. They are usually simulating type 2 diabetes. When their body determines that the blood sugar is heading for dangerous territory. That is, it will affect the general chemistry of the blood, the body cuts insulin resistance and generates insulin so that the excess blood sugar is changed into fat.

I think this is your “stingy” gene and it still exists today. In fact it is prevalent in the populations where the “stingy” gene theory would assume it would be prevalent. We can guess that the “hunter” gene was the one humans used before farming became prevalent. At that time the “hunter” gene had at least 2 problems. Women with this gene (ask any Indian, many failed monsoons in the past) have sugar problems in pregnancy. Further there is evidence that when farming first was tried this gene lead to people getting fat and then diabetic. Over evolutionary time 2 types of genetic change occurred. 1 change was the normal method of processing sugar. Other people (a minority) became more resistant to diabetes and not as prevalent to become fat. Since the normal people had this genetic history the insulin resistance could raise its (ugly?) head.


(1) 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100. (sorry I made a minor mistake in the past)

(2) Up to 1/3 of the energy in sugar is lost in storing sugar and then returning sugar to the blood.

 

[kokhongw]

(1) 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100. (sorry I made a minor mistake in the past)

This simply means you are prediabetic...you may want to go for a full OGTT to measure your insulin level as well. It may well fit Dr Joseph Krafts model.
https://profgrant.com/2013/08/16/joseph-kraft-why-hyperinsulinemia-matters/

 

[Lamont D]

Yo

I theorize that the hunter gene allows people to only store sugar when their blood sugar rises above some value (2). Consider the following. Evolutionary changes are often additions to existing processes. Women with the “hunter” gene have insulin resistance in pregnancy. Insulin is needed to process protein. Look at my glucose tolerance test (1). I am lead to the following weird conclusion. With the “hunter” gene people are normally in a state of insulin resistance. They are usually simulating type 2 diabetes. When their body determines that the blood sugar is heading for dangerous territory. That is, it will affect the general chemistry of the blood, the body cuts insulin resistance and generates insulin so that the excess blood sugar is changed into fat.

I think this is your “stingy” gene and it still exists today. In fact it is prevalent in the populations where the “stingy” gene theory would assume it would be prevalent. We can guess that the “hunter” gene was the one humans used before farming became prevalent. At that time the “hunter” gene had at least 2 problems. Women with this gene (ask any Indian, many failed monsoons in the past) have sugar problems in pregnancy. Further there is evidence that when farming first was tried this gene lead to people getting fat and then diabetic. Over evolutionary time 2 types of genetic change occurred. 1 change was the normal method of processing sugar. Other people (a minority) became more resistant to diabetes and not as prevalent to become fat. Since the normal people had this genetic history the insulin resistance could raise its (ugly?) head.


(1) 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100. (sorry I made a minor mistake in the past)

(2) Up to 1/3 of the energy in sugar is lost in storing sugar and then returning sugar to the blood.

You have a two hour peak and going steadily down by three hours.
Classic RH numbers, I would like to see the in between readings and the four hour readings.
There would be no sugar in your body once the digestion process turns it into glucose. It cannot convert it back!
It is the excess insulin that turns to visceral fat.

 

[yetta2mymom]

In Dr Bernstein's latest webinar, he talked specifically about PCOS and how difficult it is for people to lose weight. @Galja posted the link elsewhere on the forum. He talked about people not losing weight and appearing to "live on air"

Hi

The "hunter" gene (you do not store sugar unless absolutely necessary) leads to difficulty losing weight. Look at results of a glucose tolerance test. The "hunter" gene was defined as a GTT which slows its rise but is still rising after 2 hrs. The gene is prevalent in the Near East probably because they have had many failed monsoons (anecdotes with many women, I am old so not shy). As I indicated everyone doesn't have this, probably very ancient gene, because women can't turn off their insulin resistance in pregnancy. We didn't have grains before their were farmers, so there was much less of a problem. I am losing weight at the present time by eating a severe Atkins diet with no cheese or other obvious fats. My (many?) meat portions are normal (small for our society). I have gained weight on a severe Atkins diet when I ate too much fat. Some energy is lost in processing protein (protein becomes sugar + (word?)). I lost about 80 lbs on a crash (nearly starvation) diet of pasta and cottage cheese with low carbohydrate vegetables in about a year (when my blood pressure took off). It took me many years to gain back about 60 pounds. I think with my severe Atkins style diet I have removed the reason for the b.p. problem (too much insulin) I am now cutting my b.p. medicine. Without sugar my blood fats are fine.

 

[yetta2mymom]

Yo


You have a two hour peak and going steadily down by three hours.
Classic RH numbers, I would like to see the in between readings and the four hour readings.
There would be no sugar in your body once the digestion process turns it into glucose. It cannot convert it back!
It is the excess insulin that turns to visceral fat.

Hi

I guess you think your fat is never turned back into sugar. I would never take a glucose tolerance test because my sugar processing system was fouled up in 1957 (think what happens when you get type 1 diabetes (stopped losing weight after about 2 months) with no additional thrust). I had chronic fatigue for about 50 years (no fun, varied enough so I sort of functioned). It took about 2 years after I went on this severe Atkins style diet before I was nearly normal (still have unusual symptoms). I did not like the sudden drops of pulse rate (vasovagal problems).

 

[yetta2mymom]

@yetta2mymom

I would also point out that the OP has shown no signs of any scientific approach or training. In fact some of the responses have been both unpleasant and unscientific.

I (and probably others) would, of course, welcome some details of Universities attended, qualifications achieved, papers published, posts held in scientific establishments and any other evidence to back up the claim of being a scientist.

Hi

Obviously I found your original comment offensive.

 

[yetta2mymom]

This simply means you are prediabetic...you may want to go for a full OGTT to measure your insulin level as well. It may well fit Dr Joseph Krafts model.
https://profgrant.com/2013/08/16/joseph-kraft-why-hyperinsulinemia-matters/

Hi
I took this glucose tolerance test in 1964. You have given the misdiagnosis of many people. The doctor who named the "hunter" gene described this GTT as found with people who did not lose weight on his weight loss diet. I have a relative who had a similar experience.

Neil

 

[yetta2mymom]

@ickihun,

Even though, I have now lost a lot of weight.
A lot of my gradual weight gain was due to excessive insulin converting to visceral fat.
I know you have heard all the reasons for it and no matter what you do or eat, you still gain weight. The reason is not how much you eat, it is usually some food or drink that triggers the excess insulin, it could be anything, and if I have learned anything, it's that it could be anything including protein.
Unless you obsessively test and record everything you might or might not find out.
Also, having PCOS and your thyroid will not help with your other hormones.

A family member has the same issues, with general anxiety disorder on top, but she has one hyperthyroidism and one hypothyroidism to deal with, she has lost a little but rebounds quickly if she eats more than her body needs and creates more insulin, cortisol and her hormones are all over the place especially during that time of the month! (Hate discussing woman's things!) She has been eating very low carb and feels better but the weight goes nowhere!

Insulin resistance will not go away until you get really good control of your hormones, and that is so difficult to find out why you react to something that can't possibly put weight on but it does!
If I remember fasting didn't work for you or you feel awful after a while.
That's what got rid of my insulin resistance and started my weight loss and once I started it fell off quickly. I learned a lot from my fasting stay in hospital and how good I felt and how rejuvenated I was and the energy levels were something to behold.
Just by fasting for a few days.
I still fast intermittently, because of my working life.
You may have to rethink your lifestyle and see how you do experimenting with foods that you don't think would spike you.
I'm just thinking outside the box to try and help you.
I could be totally wrong though!

Hi

Now that I do not eat grains,fruit etc.. I am fine. I think my explanation is fine. I have always had a tendency to become fat as do all the "hunter" gene people. I was fine except for the overweight before I had a probable autoimmune response in 1957. The weight loss doctor who found the "hunter" gene said it occurred in only about 10% of his patients. You are probably some one in the other 90%. I have tried,tried, tried to find out who it was.

 

[yetta2mymom]

Ickihun, Professor Taylor explains insulin resistance very well, and very simply in many of his presentations, using a bicycle analogy. Have a watch sometime.

Hi
The "hunter" gene people are generally insulin resistant until there sugar is getting too high. I have inquired and nobody has a good answer of how they do this. I guess this is the original way people processed sugar.

 

[yetta2mymom]

@yetta2mymom

I would also point out that the OP has shown no signs of any scientific approach or training. In fact some of the responses have been both unpleasant and unscientific.

I (and probably others) would, of course, welcome some details of Universities attended, qualifications achieved, papers published, posts held in scientific establishments and any other evidence to back up the claim of being a scientist.

Hi

I have bounced my theories off probably the world expert on adrenal problems. He is the only doctor who had enough confidence and humility to email with me. I gather he thinks the theories are possible or even probable but not proved.

 

[azure]

Hi
The "hunter" gene people are generally insulin resistant until there sugar is getting too high. I have inquired and nobody has a good answer of how they do this. I guess this is the original way people processed sugar.

Insulin resistance doesn't switch on and off - it's more likely that their insulin response finally kicked in or they produced enough insulin to overcome the high sugar.

Have you looked at the phases of insulin response as I suggested earlier?

 

[LittleGreyCat]

Hi

I have bounced my theories off probably the world expert on adrenal problems. He is the only doctor who had enough confidence and humility to email with me. I gather he thinks the theories are possible or even probable but not proved.

So you emailed a scientist. This does NOT make you a scientist.

You have repeatedly claimed to be a scientist, to the extent that you have upset others on this forum because they apparently thought you were talking down to them.

So - are you a scientist, or just someone who emails scientists?