Remission through weight loss

[Alexandra100]

"At the conclusion of 12-months, 24% of experimental arm participants achieved a weight loss of 15 kg, which was not seen in control group. Mean weight loss of 10 kilograms was achieved in the intervention group, while subjects following best-practice guidelines achieved a weight loss of 1 kg. Out of 149 patients, 68 patients, or 46% of subjects in the experimental arm achieved complete diabetes remission, compared to 4% of patients in the control group. The remission was statistically significant, p-value <0.0001. With the respect to HbA1c reduction, experimental group subjects experienced a greater decrease of A1c by -0.85% compared to control, p<0.0001. Number of antidiabetic drugs being taken in the control group increased throughout the trial, while it was reduced in the experimental group. Out of 148 individuals, only 19 were taking any antihyperglycemic drugs at month 12 in the intervention group. In contrast, 121 out of 148 patients in the control arm were being treated with antidiabetic drugs. Although blood pressure measurements were similar across the groups at the conclusion of the trial, 61% of patients in the control group were receiving either one or two antihypertensive therapies, while only half of those did in the intervention group. Quality of life was enhanced for those patients who were randomized to the weight loss study arm. On contrary, those individuals treated according to best-practice guidelines had a decreased quality of life at the end of the study.

Significance of weight management and remission of type 2 diabetes is of crucial importance. What once was a disease of an
older individual, is now affecting a large number of youth, principally due to high incidence of obesity seen in younger population. By having a way to increase life longevity, which is reduced as a result of T2D, both younger and older individuals can achieve remission by opting for following a healthy lifestyle. We have seen here that as a result of primary care support in weight management, remission of diabetes is possible in about 50% of patients. Results from this trial are promising and may pave a road for a change in how we approach T2D treatment. Larger, multinational, randomized controlled trials are needed to see if this trial’s results will be replicated, prior to implementing changes on guideline levels."

http://www.diabetesincontrol.com/is-weight-loss-the-secret-behind-remission-of-type-2-diabetes/

 

[Resurgam]

Why does that last sentence convey such a reluctance to believe that what they were seeing was in fact something offering a glimmer of hope for all the poor souls in the grip of the standard therapies?

 

[bulkbiker]

Its just another write up of the Newcastle Diet most recent study. Their criteria for remission was HbA1c of less than 48 so still prediabetes.