COVID 2019 Comorbidity with Diabetes

Winnie53 said:

Okay, this is a long post...apologies...

I've spent the last couple of days looking for this Septic Shock/COVID-19 Protocol and I finally found it!

I encourage you to email this link and the links below to your family members so if any of you become seriously ill and require hospitalization, this document can be presented to the treatment team at the hospital... https://emcrit.org/wp-content/uploads/2020/03/COVID-ProtocolPaulMarikMD-1.pdf

Might be a good idea to forward this information and its links to your physician for review too. Read on...

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In 2017, pre-COVID-19, part of this protocol was used to successfully treat septic shock. Learn more here... https://www.evms.edu/about_evms/adm...rces&utm_content=medical#medical-professional

The protocol has since been updated to include strategies used to treat COVID-19 in China and elsewhere. (See first link above)

And here is some important background information from NPR (2017 & 2020) and JAMA (2020)...

TREATMENTS
Doctor Turns Up Possible Treatment For Deadly Sepsis

March 23, 2017 12:01 AM ET
Heard on Morning Edition

RICHARD HARRIS
Twitter

Click on the 2-Minute Listen button here then read the article... https://www.npr.org/sections/health...turns-up-possible-treatment-for-deadly-sepsis

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TREATMENTS
Vitamin Treatment For Sepsis Fails In Large Trial

January 17, 2020 8:09 AM ET

RICHARD HARRIS
Twitter

An excerpt from this article in which Dr. Marik explains why he believes, and I agree, the study failed because the treatment "is only effective if given within six hours after someone has suspected sepsis."...

"I don't think we can yet say that there is no impact," Coopersmith says. "I think we could say that the jury's still out on that."

​

He assumes that doctors who are inclined toward using the treatment will continue to do so, at least for now, while those who adopted a wait-and-see approach are sticking with that.

Indeed, Marik, who remains a strong proponent of this approach, rejects the findings of the study. He tells NPR that by his reckoning, patients in the study received treatment far too late in the course of their disease. "It's like giving it to a patient who's dead," he says. "It's of no benefit. The horse was out of the barn miles beforehand."

Marik, at Eastern Virginia Medical School, gives his patients the vitamin C infusion as quickly as he recognizes signs of sepsis. That's impossible to do in a study in which participants must be enrolled in a study and then randomized into one of the two comparison groups before treatment can begin.

"The question is, why does this study not replicate real-life experience and the experience of hundreds of clinicians around the world?" he asks.

Marik says in his experience, the treatment is only effective if given within six hours after someone has suspected sepsis. At the meeting in Belfast, Dr. Tomoko Fujii, on the study research team at Monash University, said they provided treatment an average of 12 hours after patients arrived in the intensive care unit. Patients came from a variety of locations, including the emergency room, and she said they have no information about how long they had been septic before arriving at the ICU.
Full article is here with additional links... https://www.npr.org/sections/health...min-treatment-for-sepsis-fails-in-large-trial​

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Editorial
January 17, 2020
Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis
Andre C. Kalil, MD, MPH1

"The use of vitamin C for treatment of patients with sepsis has generated substantial interest and controversy. In 2017, a single-center observational study suggested that the combination of high-dose vitamin C, thiamine, and hydrocortisone in conjunction with usual care was associated with reduced mortality (8.5% for combination treatment vs 40.4% for control).1 Despite the small sample size (94 patients), lack of concurrent controls and randomization, and important baseline imbalances between study groups, the study garnered significant attention. There were reports that some physicians were keen to adopt the strategy as part of routine practice, even though this approach had not been tested in a rigorous clinical trial."
[I don't have access to the full article...apologies...]

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So did the protocol for septic shock fail - (vitamin C 1.5 g q 6 IV; hydrocortisone 50 mg q 6 IV; thiamine [vitamin B1]; 200 mg q 12 IV)? Or did the study design?

Here's the full session in which results from the study were presented and beginning at minute 47:42 Dr. Paul E. Marik was given 15 minutes to respond to the study results...

The posts in the comments section below the video are of interest too.

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I became aware of this protocol after listening to a recent online episode of "Jimmy Rants" - (432: Why are effective natural remedies for #COVID19 #coronavirus being rejected?) - by American author and blogger Jimmy Moore (LLVLC.com) earlier this week.

A friend of his, Keith Berkowitz, MD in New York City stumbled upon Dr. Marik's protocol while searching for information on potential treatments for COVID-19 and was so impressed he immediately began promoting the protocol to doctors around the country, then asked Jimmy for his help in getting the information out to the public.

Links...

https://jimmyrants.com/why-are-effective-natural-remedies-for-covid19-coronavirus-being-rejected/ (Protocol specifically discussed beginning around minute 20:00)

https://jimmyrants.com/bonus-are-we...irus-not-enough-on-the-inflammation-response/ (Brief episode with Dr. Berkowitz in which the protocol is discussed as well as a summary of patient results from doctors around the country)

https://livinlavidalowcarb.com/keto...an-underused-but-effective-covid-19-protocol/ Jimmy and Dr. Will Cole talk further with Dr. Berkowitz about the protocol and patient results.

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I've spent days digging around for information on this septic shock/COVID-19 protocol. Hope you find it as helpful as my husband and I have. Given the shortage of ventilators, this protocol has the potential to save lives, but it needs to be initiated at the hospital within 6 hours of sepsis symptoms for best results, no more than 12 hours.

Click to expand...