The development and progression of type 1 diabetes has been successfully replicated in mice, which could help researchers understand more about the condition.
The study carried out by a US team involved adding human genes to the mice and looking at a series of T-cells that are found in the pancreas.
This new approach is pioneering because the mice also developed type 1 diabetes-related complications, which means the team can fully explore the condition and its natural progression in the animals.
Other research studies have involved trying to replicate type 1 diabetes in animals, but the outcomes have never mimicked the exact way a human develops the condition.
“Unfortunately, research has been inhibited because the scientific community didn’t have a good model to study the disease and its progression. Now, we do. We have developed a mouse model that is a step forward toward finding a cure,” said Dr Juan Jaumen, professor of medicine at the University of Toledo’s (UT) College of Medicine and Life Sciences and senior author of the research.
The team have filed a patent for their method and are now carrying out a more in-depth study to see how they can use their model to develop future prevention therapies and whether it can be applied to other conditions such as cancer.
Dr Jaume added: “The existing non-obese diabetic mouse model does not completely resemble the human condition. There are more than 125 different therapies that cure type 1 diabetes in non-obese diabetic mice. Clinical trials were developed because of that model, but none have worked in humans. Everybody has been searching for a better model.”
The findings have been published in the journal Scientific Reports.

Get our free newsletters

Stay up to date with the latest news, research and breakthroughs.

You May Also Like

Conversation about doctors’ appointments occurring virtually rumbles on

More than half of GP appointments are still being delivered remotely in…

Public Health England considers low carb approach for type 2 diabetes

The low carb approach is being considered by the government to be…

Coronavirus: UK instructed to stay at home this weekend

Health Secretary Matt Hancock has said that staying at home this weekend…