An American research team have found that inflammation rather than obesity leads to insulin resistance.
The team, from the University of California School of Medicine in San Diego, discovered that inflamed immune cells causes insulin resistance and eventually type 2 diabetes.
The findings could have a role to play in the future development of treatments to fight the diabetes epidemic. The team found that if a particular route for inflammation, the macrophage inflammatory pathway was disabled, diabetes could be prevented.
A Professor of Medicine and Associate Dean for Scientific Affairs, Jerrold Olefsky, reportedly commented: “Our research shows that insulin resistance can be disassociated from the increase in body fat associated with obesity.”
The findings also indicated that obesity without inflammation would not automatically cause insulin resistance. Olefsky reportedly concluded: “We aren’t suggesting that obesity is healthy, but indications are promising that, by blocking the macrophage pathway, scientists may find a way to prevent the Type 2 diabetes now linked to obesity and fatty livers.”

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