GAD Antibodies Test
A Glutamic Acid Decarboxylase Autoantibodies test (GAD antibodies test) is used to help discover whether someone has either type 1 diabetes or Latent Autoimmune Diabetes of Adulthood (LADA).
A GAD antibody test may be favoured as a way of testing for which type of diabetes over a c-peptide test, which measures how much insulin is being produced by the body.
What is a GAD antibodies test?
A GAD test is a blood test which measures whether the body is producing a type of antibody which destroys its own GAD cells.
In type 1 diabetes, a number of autoantibodies are thought to circulate including those which target glutamic acid decarboxylase.
Presence of these autoantibodies suggests type 1 diabetes.
Why is a GAD test performed?
The test is performed to help determine which type of diabetes someone has.
The test is particularly useful for adults over 30 who get diabetes where a type 2 diabetes diagnosis is in doubt - such as if the patient is not overweight.
The test may also be used to determine whether gestational diabetes (diabetes within pregnancy) may be type 1 diabetes. The test can also be used to measure the progression of type 1 diabetes or indicate a risk of type 1 diabetes or LADA.
How is a GAD Autoantibody test done?
To carry out the test a blood sample is taken from the patient’s arm. The test should be done before insulin therapy is started. The blood sample will need to be sent to be analysed by a lab before results can be obtained.
What will the GAD test results show?
Presence of the GAD antibodies is observed in 75% of people with type 1 diabetes at diagnosis.
If the test shows GAD antibodies are present, this indicates that the patient has type 1 diabetes. If no GAD antibodies are present, however, the test cannot be conclusive in saying that the patient does not have type 1 diabetes.