Researchers at the Children’s Hospital in Boston are trialling a new approach to treating both type 1 and 2 diabetes without the use of insulin . The study has shown that blood sugar levels can be normalised without involving insulin, which is hoped could provide a new therapeutic approach for treating diabetes .
Lead researcher, Umut Ozcan, who is a physician in the Division of Endocrinology at the Children’s Hospital, has revealed in the laboratory that when the regulatory protein XBP-1s activated artificially in the liver, it can normalise high levels of blood sugar in both lea, insulin-deficient type 1 diabetic mice and obese, insulin-resistant type 2 diabetic mice. These findings show that approaches for increasing XBP-1s activity could benefit patients with diabetes.
Ozcan commented “Activating XBP-1s could be another approach to type 2 diabetes, and could be very beneficial for type 1 diabetes, too. Even in mice with no insulin, increased expression of XBP-1s lowered the blood glucose level significantly.”
He added “This suggests that approaches that activate XBP-1s in the liver of type 1 diabetics could control blood glucose levels, with potentially much less requirement for insulin.”
He hopes now to uncover realistic ways to activate XBP-1s that could be clinically developed.

Get our free newsletters

Stay up to date with the latest news, research and breakthroughs.

You May Also Like

Public Health England considers low carb approach for type 2 diabetes

The low carb approach is being considered by the government to be…

Coronavirus: UK instructed to stay at home this weekend

Health Secretary Matt Hancock has said that staying at home this weekend…

Type 2 diabetes found to be a ‘significant risk factor’ among stroke victims

More evidence has been published which supports that diabetes is a “significant…