People living with obesity can experience the weight loss benefits of GLP-1 receptor agonists even if they do not have diabetes, new research has shown.

Latest evidence has identified that GLP-1 receptor agonists (GLP-1 RAs) can help people living with overweight or obesity lose up to 10% of their body weight.

Academics have revealed that semaglutide is more beneficial than tirzepatide and liraglutide when it comes to achieving weight loss.

Initially, GLP-1 RAs were approved to treat type 2 diabetes; however, recent trials have highlighted that they can also trigger weight loss.

During the study, the team of scientists analysed the weight loss outcomes of 8,847 adults with a BMI of ≥30 kg/m² or ≥27 kg/m², all of whom had at least one weight-related comorbidity.

Participants had to either take liraglutide, semaglutide, tirzepatide or a placebo. In addition, they all had to regularly exercise, eat a low-calorie diet and attend lifestyle counselling sessions.

The results have shown that the participants taking GLP-1 RAs experienced better weight loss than those on the placebo.

Additionally, the findings have revealed that semaglutide was associated with better weight loss results than tirzepatide and liraglutide.

However, some side effects were reported among the participants in the GLP-1 RA group, including vomiting, abdominal pain, diarrhoea, nausea and constipation.

Tirzepatide was also linked to a higher risk of alopecia, the study has reported.

The study stated: “Treatment discontinuation due to adverse effects was more than twice as high in the GLP-1 RA group compared to placebo.”

To read the study, click here.

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